2. PROTAC
  3. PROTAC Linkers
  4. DBCO-mPEG (MW 20kDa)

DBCO-mPEG (MW 20kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-mPEG (MW 20kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-mPEG (MW 20kDa) Chemical Structure

DBCO-mPEG (MW 20kDa) Chemical Structure

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DBCO-mPEG (MW 20kDa) Related Antibodies

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Description

DBCO-mPEG (MW 20kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-mPEG (MW 20kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-mPEG (MW 20kDa) Related Antibodies
Molecular Weight

20000(Average)

SMILES

O=C(CCC(NCCOCCOC)=O)N1CC2=CC=CC=C2C#CC3=C1C=CC=C3.[n].[MW 20kDa]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DBCO-mPEG (MW 20kDa) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-mPEG (MW 20kDa)PROTAC LinkersInhibitorinhibitorinhibit

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