2. Epigenetics PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. AMPK Mitochondrial Metabolism
  4. DBI-2

DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells.

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DBI-2 Chemical Structure

DBI-2 Chemical Structure

CAS No. : 2939087-00-8

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DBI-2 Related Antibodies

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Description

DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells[1].

In Vitro

The IC50 of DBI-2 to inhibit the proliferation of LS174T cells and HCT116 cells was 1.14 μM and 0.53 μM, respectively[1].
DBI-2 (3 μM; 24 h) induces growth suppression by activating AMPK and inhibiting the mTOR and Wnt pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBI-2 Related Antibodies

Western Blot Analysis[1]

Cell Line: LS174T CRC cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Increased p-AMPK and p-ACC, and decreased p-P70S6K and p-S6, and reduced the expression of Axin2 and c-Myc.
In Vivo

DBI-2 (40 mg/kg; ip; for 12 days) inhibits tumor growth in olorectal cancer (CRC) xenograft mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: RAG1−/− γc− mice injected with S174T cells[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal administration; for 12 days
Result: Suppressed of tumor growth.
Molecular Weight

473.40

Formula

C24H29BrN2O3
CAS No.
SMILES

CN(CCN(C)CCCCOC1=CC=C2C(OC=C(C3=CC=C(Br)C=C3)C2=O)=C1)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DBI-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBI-22939087-00-8DBI2DBI 2AMPKMitochondrial MetabolismAMP-activated protein kinaseAMPK activatormitochondrial complex IOXPHOScolorectal cancerInhibitorinhibitorinhibit

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