2. PROTAC Epigenetics
  3. PROTACs Histone Acetyltransferase
  4. dCE-2

dCE-2 is a PROTAC targeting CBP/EP300. dCE-2 consists of E3 ubiquitin ligase ligand Thalidomide-4-OH (HY-103596), PROTAC Linker tert-Butyl 11-aminoundecanoate (HY-130715) and PROTAC target protein ligand EP300/CBP ligand 2 (HY-161960), of which the target protein ligand activity control is EP300/CBP ligand 1 (HY-161959), and the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C10-Boc (HY-161961).

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dCE-2 Chemical Structure

dCE-2 Chemical Structure

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dCE-2 Related Antibodies

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Description

dCE-2 is a PROTAC targeting CBP/EP300. dCE-2 consists of E3 ubiquitin ligase ligand Thalidomide-4-OH (HY-103596), PROTAC Linker tert-Butyl 11-aminoundecanoate (HY-130715) and PROTAC target protein ligand EP300/CBP ligand 2 (HY-161960), of which the target protein ligand activity control is EP300/CBP ligand 1 (HY-161959), and the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C10-Boc (HY-161961)[1].

IC50 & Target

CBP/EP300[1]
Molecular Weight

797.90

Formula

C44H47N9O6
SMILES

O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCCCCCCCCCC(NC4=CC(C5=NN(C)C=C5)=CC(C(NC6=CC=CC7=C6C=C(C)N=N7)=O)=C4)=O)=C3C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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dCE-2 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dCE-2dCE2dCE 2PROTACsHistone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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