2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-NH-C10-Boc

Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958).

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Thalidomide-NH-C10-Boc Chemical Structure

Thalidomide-NH-C10-Boc Chemical Structure

CAS No. : 2428400-25-1

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Thalidomide-NH-C10-Boc Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958)[1].

Molecular Weight

513.63

Formula

C28H39N3O6
CAS No.
SMILES

O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCCCCCCCCCC(OC(C)(C)C)=O)=C3C1=O
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References
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Thalidomide-NH-C10-Boc Related Classifications

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Keywords:

Thalidomide-NH-C10-Boc2428400-25-1E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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