DCE_42

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DCE_42 is a potent EZH2 inhibitor with an IC₅₀ value of 22.6 µM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma.

For research use only. We do not sell to patients.

DCE_42 Chemical Structure

CAS No. : 669749-45-5

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•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

DCE_42 is a potent EZH2 inhibitor with an IC₅₀ value of 22.6 µM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma^[1].

IC₅₀ & Target^[1]

EZH2

22.6 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
DB	IC₅₀	32.8 μM Compound: DCE_42	Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay	[PMID: 27289323]
Toledo	IC₅₀	24.1 μM Compound: DCE_42	Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay	[PMID: 27289323]

In Vitro

DCE_42 inhibits Toledo and DB cell proliferation with IC₅₀ values of 24.1, 32.8 µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.51

Formula

C₂₂H₁₉N₉O₂S

CAS No.

669749-45-5

SMILES

O=C1NC(NC2=NC(C)=C3C=C(C=CC3=N2)OC)=NC(CSC4=NN=NN4C5=CC=CC=C5)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3813-7. [Content Brief]

DCE_42 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCE_42669749-45-5Histone MethyltransferaseToledoDB cellsproliferationlymphomaInhibitorinhibitorinhibit

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