2. Protein Tyrosine Kinase/RTK
  3. Discoidin Domain Receptor
  4. DDR1/2 inhibitor-2

DDR1/2 inhibitor-2 (Example 31) is a DDR1/DDR2 inhibitor, with IC50 values less than 100 nM. DDR1/2 inhibitor-2 can be used for research of cancer and fibrotic diseases.

For research use only. We do not sell to patients.

DDR1/2 inhibitor-2 Chemical Structure

DDR1/2 inhibitor-2 Chemical Structure

CAS No. : 2908756-11-4

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1 mg USD 380 In-stock
5 mg USD 650 In-stock
10 mg USD 980 In-stock
25 mg USD 1750 In-stock
50 mg USD 2650 In-stock
100 mg USD 3950 In-stock
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Based on 1 publication(s) in Google Scholar

DDR1/2 inhibitor-2 Related Antibodies

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DDR1 DDR2

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Description

DDR1/2 inhibitor-2 (Example 31) is a DDR1/DDR2 inhibitor, with IC50 values less than 100 nM. DDR1/2 inhibitor-2 can be used for research of cancer and fibrotic diseases[1].

IC50 & Target

DDR1

 

DDR2

 

Molecular Weight

492.45

Formula

C25H19F3N6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CN1C=CC2=C(C1=O)C(NC3=CC(C=NN4C)=C4C=C3)=CC=C2)NC5=CN=CC(C(F)(F)F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (33.85 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0307 mL 10.1533 mL 20.3066 mL
5 mM 0.4061 mL 2.0307 mL 4.0613 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0307 mL 10.1533 mL 20.3066 mL 50.7666 mL
5 mM 0.4061 mL 2.0307 mL 4.0613 mL 10.1533 mL
10 mM 0.2031 mL 1.0153 mL 2.0307 mL 5.0767 mL
15 mM 0.1354 mL 0.6769 mL 1.3538 mL 3.3844 mL
20 mM 0.1015 mL 0.5077 mL 1.0153 mL 2.5383 mL
25 mM 0.0812 mL 0.4061 mL 0.8123 mL 2.0307 mL
30 mM 0.0677 mL 0.3384 mL 0.6769 mL 1.6922 mL
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DDR1/2 inhibitor-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDR1/2 inhibitor-22908756-11-4Discoidin Domain ReceptorCancerfibrotic diseaseInhibitorinhibitorinhibit

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