Deltasonamide 1 TFA

Name: Deltasonamide 1 TFA
Brand: MedChemExpress
SKU: HY-122641D
Rating: 4.5 (1 reviews)

Cat. No.: HY-122641D: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a K_D of 203 pM. Deltasonamide 1 can be used for the research of tumors.

For research use only. We do not sell to patients.

Deltasonamide 1 TFA Chemical Structure

CAS No. : 2235358-73-1

Size	Price	Stock	Quantity
1 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2580	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Deltasonamide 1 TFA:

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•Related Small Molecules:

•Related Proteins:

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
Customer Review

Description

Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a K_D of 203 pM. Deltasonamide 1 can be used for the research of tumors^[1].

IC₅₀ & Target

KD: 203 pM (PDE6δ-KRas)^[1]

In Vitro

Deltasonamide 1 can inhibit PDE6δ-KRas with a K_D of 203 pM^[1].
Deltasonamide 1 binds to PDE6δ with up to 7 hydrogen bonds, resulting in picomolar affinity^[1].
Deltasonamide 1 strongly reduces proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	RTCA of hPDAC cell lines
Concentration:	0.375, 0.75, 1.5, 3, 6, 12 μM
Incubation Time:	60 h
Result:	Inhibited proliferation of human pancreatic cancer cell lines.

Molecular Weight

761.27

Formula

C₃₂H₄₀ClF₃N₆O₆S₂

CAS No.

2235358-73-1

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(S(=O)(N(CC2=NC(NC)=NC=C2)CC3CCNCC3)=O)C=C1)(N(CC4=CC=C(Cl)C=C4)C5CCCC5)=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 200 mg/mL (262.72 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3136 mL	6.5680 mL	13.1359 mL
5 mM	0.2627 mL	1.3136 mL	2.6272 mL
10 mM	0.1314 mL	0.6568 mL	1.3136 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (264 KB) RP-HPLC (96 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Pablo Martín-Gago, et al. A PDE6δ-KRas Inhibitor Chemotype With Up to Seven H-Bonds and Picomolar Affinity That Prevents Efficient Inhibitor Release by Arl2. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.3136 mL	6.5680 mL	13.1359 mL	32.8399 mL
	5 mM	0.2627 mL	1.3136 mL	2.6272 mL	6.5680 mL
	10 mM	0.1314 mL	0.6568 mL	1.3136 mL	3.2840 mL
	15 mM	0.0876 mL	0.4379 mL	0.8757 mL	2.1893 mL
	20 mM	0.0657 mL	0.3284 mL	0.6568 mL	1.6420 mL
	25 mM	0.0525 mL	0.2627 mL	0.5254 mL	1.3136 mL
	30 mM	0.0438 mL	0.2189 mL	0.4379 mL	1.0947 mL
	40 mM	0.0328 mL	0.1642 mL	0.3284 mL	0.8210 mL
	50 mM	0.0263 mL	0.1314 mL	0.2627 mL	0.6568 mL
	60 mM	0.0219 mL	0.1095 mL	0.2189 mL	0.5473 mL
	80 mM	0.0164 mL	0.0821 mL	0.1642 mL	0.4105 mL
	100 mM	0.0131 mL	0.0657 mL	0.1314 mL	0.3284 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.