2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Dendrotoxin-I TFA

Dendrotoxin-I TFA  (Synonyms: DTX-I TFA)

Cat. No.: HY-P3055A Purity: 97.24%
SDS COA Handling Instructions Technical Support

Dendrotoxin-I (DTX-I) TFA is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research.

For research use only. We do not sell to patients.

Dendrotoxin-I TFA Chemical Structure

Dendrotoxin-I TFA Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dendrotoxin-I TFA:

Dendrotoxin-I TFA Related Antibodies

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Description

Dendrotoxin-I (DTX-I) TFA is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research[1][2][3].

IC50 & Target[1]

Kv1.1

0.13-50 nM (IC50)

Kv1.2

0.13-50 nM (IC50)

Kv1.6

0.13-50 nM (IC50)

In Vivo

Dendrotoxin-I (5 mg/kg; IV) TFA displays a significant tumor growth inhibition effect combined with hyperthermia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with MCF-7 cells[3]
Dosage: 5 mg/kg
Administration: IV
Result: Displayed a significanttumor growth inhibition effect combined with hyperthermia.
Could not keep on inhibiting the growth of tumor at the later period of treatment.
Molecular Weight

7149.24 (free acid)

Formula

C312H491N99O83S6.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Gln-Pro-Leu-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Gln-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Gly-Phe-Thr-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Arg-Lys (Disulfide bridge:Cys7-Cys57;Cys16-Cys40;Cys32-Cys53)
Sequence Shortening

QPLRKLCILHRNPGRCYQKIPAFYYNQKKKQCEGFTWSGCGGNSNRFKTIEECRRTCIRK (Disulfide bridge:Cys7-Cys57;Cys16-Cys40;Cys32-Cys53)
SMILES

O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC2=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N4[C@@H](CCC4)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(NCC(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@H]6CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N9[C@@H](CCC9)C(N[C@@H](C)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CC%12=CC=C(C=C%12)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H]2[C@H](O)C)=O)=O)=O)NC6=O)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC%13=CC=CC=C%13)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC%14=CNC%15=CC=CC=C%14%15)C(N[C@@H](CO)C(NCC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(N)=O)N.O=C(C(F)(F)F)O.[x]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

0.05 M Sodium acetate : 50 mg/mL (adjust pH to 3 with CH3COOH)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 97.24%

COA (263 KB) RP-HPLC (112 KB) MS (210 KB)

Handling Instructions (2659 KB)
References
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Dendrotoxin-I TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dendrotoxin-IDTX-IPotassium ChannelKcsAvoltage-gated potassium channelneurotoxinDendroaspis snakescancerInhibitorinhibitorinhibit

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