2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Dendrotoxin-I

Dendrotoxin-I (DTX-I) is a potent K+ channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research.

For research use only. We do not sell to patients.

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Dendrotoxin-I Chemical Structure

Dendrotoxin-I Chemical Structure

CAS No. : 107950-33-4

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Dendrotoxin-I Related Antibodies

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Description

Dendrotoxin-I (DTX-I) is a potent K+ channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research[1][2][3].

IC50 & Target[1]

Kv1.1

0.13-50 nM (IC50)

Kv1.2

0.13-50 nM (IC50)

Kv1.6

0.13-50 nM (IC50)

In Vivo

Dendrotoxin-I (5 mg/kg; IV) displays a significant tumor growth inhibition effect combined with hyperthermia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with MCF-7 cells[3]
Dosage: 5 mg/kg
Administration: IV
Result: Displayed a significanttumor growth inhibition effect combined with hyperthermia.
Could not keep on inhibiting the growth of tumor at the later period of treatment.
Molecular Weight

7149.24

Formula

C312H491N99O83S6
CAS No.
Sequence

Gln-Pro-Leu-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Gln-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Gly-Phe-Thr-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Arg-Lys (Disulfide bridge:Cys7-Cys57;Cys16-Cys40;Cys32-Cys53)
Sequence Shortening

QPLRKLCILHRNPGRCYQKIPAFYYNQKKKQCEGFTWSGCGGNSNRFKTIEECRRTCIRK (Disulfide bridge:Cys7-Cys57;Cys16-Cys40;Cys32-Cys53)
Structure Classification
Initial Source

Dendroaspis polylepis and angusticeps
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dendrotoxin-I Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dendrotoxin-I107950-33-4DTX-IPotassium ChannelKcsAvoltage-gated potassium channelneurotoxinDendroaspis snakescancerInhibitorinhibitorinhibit

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