DENV-IN-6

Cat. No.: HY-143273: FAQs
Data Sheet Handling Instructions

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DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC₅₀s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1_IIIB (EC₅₀=0.0181 µM; CC₅₀=64.92 µM).

For research use only. We do not sell to patients.

DENV-IN-6 Chemical Structure

CAS No. : 2375780-95-1

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

HIV (IIIB)

In Vitro

DENV-IN-6 (compound 4a) (0.04, 0.2, 1, 5, 25 μM; 5 days) shows inhibitory effect on replication of DENV (I-IV) in a dose-dependent manner (EC₅₀s=17.5, 13.20, 6.8 and 11.41 μM, respectively)^[1].
DENV-IN-6 (25 μM; 5 days) shows low toxic to Vero cells (CC₅₀＞200 μM) and exhibits stronger inhibitory effect on DENV-III than on DENV-I, II, IV with a TI value is greater than 29.41 (Therapeutic index (TI): ratio CC₅₀/IC₅₀)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Vero cells
Concentration:	0.04, 0.2, 1, 5, 25 μM
Incubation Time:	5 days
Result:	Surpressed replication of DENV (I-IV) in a dose-dependent manner and with EC₅₀s of 17.5, 13.20, 6.8 and 11.41 μM, respectively.

Cell Cytotoxicity Assay^[1]

Cell Line:	Vero cells
Concentration:	25 μM
Incubation Time:	5 days
Result:	Exhibited low toxic to Vero cells with a CC₅₀ value was greater than 200 μM. Showed stronger inhibitory effect on DENV-III than on DENV-I, II, IV (Therapeutic index (TI) values of DENV (I-IV):＞11.43, ＞15.15, ＞29.41, ＞17.53).

Molecular Weight

461.00

Formula

C₂₃H₂₆ClFN₄OS

CAS No.

2375780-95-1

SMILES

CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC=C(C=C3)F)=C2Cl)CC4CCCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rui RM, et al. C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity. Bioorg Chem. 2022 Feb;119:105494. [Content Brief]

DENV-IN-6 Related Classifications

Infection

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DENV-IN-62375780-95-1HIVDNA/RNA SynthesisHuman immunodeficiency virusDENVHIV-1VeroAntiviral activityInhibitorinhibitorinhibit

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