2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Desirudin

Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction.

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Desirudin Chemical Structure

Desirudin Chemical Structure

CAS No. : 120993-53-5

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Desirudin Related Antibodies

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Description

Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction[1][2].

IC50 & Target

ED50: 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2].
In Vivo

Desirudin (CGP 39393, 0.75-3.0 mg/kg, a bolus plus infusion administration, dogs model of cardiopulmonary bypass) is effective in Inhibiting clot formation[1].
Desirudin (0.01-1 mg/kg, Intravenous injections and subcutaneous injection, rat shunt model) inhibits thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.), and inhibits venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs model of cardiopulmonary bypass[1]
Dosage: 1.0 mg/kg + 0.75 mg/kg/h, 1.0 mg/kg + 1.50 mg/kg/h, 1.0 mg/kg + 2.25 mg/kg/h, 1.0 mg/kg + 3.0 mg/kg/h.
Administration: Administered as a bolus plus infusion
Result: Inhibited clot formation with no adverse hemodynamic or hematologic effects.
Animal Model: Rat shunt model of thrombus formation on a cotton-thread[2]
Dosage: 0.01-1 mg/kg approximately
Administration: Intravenous injections, subcutaneous injection
Result: Inhibited thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.).
Inhibited venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.).
Clinical Trial
CAS No.
SMILES

[desirudin]
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Desirudin Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desirudin120993-53-5CGP 39393 RevascCGP39393CGP-39393ThrombinRecombinant hirudinantithromboticclot formationheparin-induced thrombocytopeniaInhibitorinhibitorinhibit

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