2. Metabolic Enzyme/Protease
  3. Drug Metabolite Cytochrome P450
  4. Desmethyl Bosentan

Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.

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Desmethyl Bosentan Chemical Structure

Desmethyl Bosentan Chemical Structure

CAS No. : 253688-61-8

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.

Molecular Weight

537.59

Formula

C26H27N5O6S
CAS No.
SMILES

O=S(NC1=C(OC2=C(O)C=CC=C2)C(OCCO)=NC(C3=NC=CC=N3)=N1)(C4=CC=C(C(C)(C)C)C=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Desmethyl Bosentan Related Classifications

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Keywords:

Desmethyl Bosentan253688-61-8Ro 47-8634Drug MetaboliteCytochrome P450CYPsInhibitorinhibitorinhibit

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