Desmorpholinyl Quizartinib-PEG2-COOH

Cat. No.: HY-131230 Purity: 95.09%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC₅₀ 0.6 nM.

For research use only. We do not sell to patients.

Desmorpholinyl Quizartinib-PEG2-COOH Chemical Structure

CAS No. : 2292116-14-2

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 265	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 530	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

607.68

Formula

C₃₀H₃₃N₅O₇S

CAS No.

2292116-14-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCOCCOCCOC1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(NC(NC5=NOC(C(C)(C)C)=C5)=O)C=C4)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (164.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6456 mL	8.2280 mL	16.4560 mL
5 mM	0.3291 mL	1.6456 mL	3.2912 mL
10 mM	0.1646 mL	0.8228 mL	1.6456 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.09%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (243 KB) HNMR (268 KB) LCMS (122 KB)

Handling Instructions (2659 KB)

References

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6456 mL	8.2280 mL	16.4560 mL	41.1401 mL
	5 mM	0.3291 mL	1.6456 mL	3.2912 mL	8.2280 mL
	10 mM	0.1646 mL	0.8228 mL	1.6456 mL	4.1140 mL
	15 mM	0.1097 mL	0.5485 mL	1.0971 mL	2.7427 mL
	20 mM	0.0823 mL	0.4114 mL	0.8228 mL	2.0570 mL
	25 mM	0.0658 mL	0.3291 mL	0.6582 mL	1.6456 mL
	30 mM	0.0549 mL	0.2743 mL	0.5485 mL	1.3713 mL
	40 mM	0.0411 mL	0.2057 mL	0.4114 mL	1.0285 mL
	50 mM	0.0329 mL	0.1646 mL	0.3291 mL	0.8228 mL
	60 mM	0.0274 mL	0.1371 mL	0.2743 mL	0.6857 mL
	80 mM	0.0206 mL	0.1029 mL	0.2057 mL	0.5143 mL
	100 mM	0.0165 mL	0.0823 mL	0.1646 mL	0.4114 mL