2. Induced Disease Models Products Anti-infection
  3. Immunology and Inflammatory Disease Models Bacterial
  4. Paw Edema Models
  5. Dextran

Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.

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Dextran Chemical Structure

Dextran Chemical Structure

CAS No. : 9004-54-0

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Description

Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.

In Vivo

Dextran can be used in animal modeling to create paw edema models. Injection of dextran at doses of either 7.9 mg/kg or 300 mg/kg results in edema of equal intensity in the limbs[1][2].

Induction of paw edema[1][2].
Background
Dextran promotes the release of histamine and serotonin from mast cells during edema formation. These substances alter the tone and vascular permeability, contributing to fluid extravasation[1][2].
Specific Mmodeling Methods
Mice: Swiss albino• male • weighing 25-30 g[1].
Administration: 1% dextran (20 μL/paw)• intraplantar injection in the right hind paw• a single dose for 1, 2, 3 and 4 h[1].
Rat: Albino of of the Sprague Dawleq strain• weighing 110-130 g• seven-week-old[2].
Administration: 0.5 mL/100 g • tail vein injection• a single dose[2].
Note
(1)Dextran (6% v/w in saline) was freshly diluted each day so as to contain 7.9 mg or 600 mg per 5 ml volume of physiological saline[2].
Modeling Indicators
Morphological change: Developed marked inflammatory reaction and significantly increased the volume of paw edema[1].
Histological analysis: Mast-cell disruption (histamine and serotonili release), vasodilatation, hypothermia, hypotension, helnoconcentration and edema occurred with the high doses of Dextran. Since minute doses of dextran induced only vasodilatation and edema formation[2].
Correlated Product(s): Carrageenan (HY-125474); Histamine (HY-B1204); Arachidonic acid (HY-109590)[1].
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

40000.00

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (2.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.0250 mL 0.1250 mL 0.2500 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 166.67 mg/mL (4.17 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.0250 mL 0.1250 mL 0.2500 mL 0.6250 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dextran Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dextran9004-54-0Dextran 40Dextran40Dextran-40BacterialInhibitorinhibitorinhibit

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