DHFR-IN-5

Cat. No.: HY-153007 Purity: 99.27%: FAQs
Data Sheet SDS COA Handling Instructions

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DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a K_i value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity.

For research use only. We do not sell to patients.

DHFR-IN-5 Chemical Structure

CAS No. : 1142407-81-5

Size	Price	Stock	Quantity
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 740	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of DHFR-IN-5:

DHFR-IN-5 hydrochloride Get quote

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Description

In Vitro

DHFR-IN-5 (compound p218) shows highly active against PYR-resistant P. falciparum with IC₅₀s of 4.6, 56 nM for wild-type P. falciparum (TM4), quadruple mutant P. falciparum (V1/S), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DHFR-IN-5 (compound p218) (30 mg/kg; p.o.) shows anti-malaria activity with good oral bioavailability (46.3%), a reasonable half-life (7.3 h) in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[1]
Dosage:	30 mg/kg
Administration:	P.o.
Result:	Showed good oral bioavailability (46.3%), a reasonable half-life (7.3 h), and minimal distribution into the brain.

Molecular Weight

360.41

Formula

C₁₈H₂₄N₄O₄

CAS No.

1142407-81-5

Appearance

Solid

Color

Off-white to gray

SMILES

O=C(CCC1=C(OCCCOC2=C(CC)N=C(N)N=C2N)C=CC=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.27%

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Data Sheet (268 KB) SDS (251 KB)

COA (248 KB) HNMR (269 KB) RP-HPLC (257 KB) LCMS (107 KB)

Handling Instructions (2659 KB)

References

[1]. Yuthavong Y, et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. [Content Brief]

DHFR-IN-5 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHFR-IN-51142407-81-5Dihydrofolate reductase (DHFR)orally activePYR-resistantanti-malariaPlasmodium falciparumInhibitorinhibitorinhibit

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