DHFR-IN-5

Cat. No.: HY-153007 Purity: 99.27%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a K_i value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity.

For research use only. We do not sell to patients.

DHFR-IN-5 Chemical Structure

CAS No. : 1142407-81-5

Size	Price	Stock	Quantity
1 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 740	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of DHFR-IN-5:

DHFR-IN-5 hydrochloride Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

DHFR-IN-5 (compound p218) shows highly active against PYR-resistant P. falciparum with IC₅₀s of 4.6, 56 nM for wild-type P. falciparum (TM4), quadruple mutant P. falciparum (V1/S), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DHFR-IN-5 (compound p218) (30 mg/kg; p.o.) shows anti-malaria activity with good oral bioavailability (46.3%), a reasonable half-life (7.3 h) in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[1]
Dosage:	30 mg/kg
Administration:	P.o.
Result:	Showed good oral bioavailability (46.3%), a reasonable half-life (7.3 h), and minimal distribution into the brain.

Molecular Weight

360.41

Formula

C₁₈H₂₄N₄O₄

CAS No.

1142407-81-5

Appearance

Solid

Color

Off-white to gray

SMILES

O=C(CCC1=C(OCCCOC2=C(CC)N=C(N)N=C2N)C=CC=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.27%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (248 KB) HNMR (269 KB) RP-HPLC (257 KB) LCMS (107 KB)

Handling Instructions (2659 KB)

References

[1]. Yuthavong Y, et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. [Content Brief]

DHFR-IN-5 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHFR-IN-51142407-81-5Dihydrofolate reductase (DHFR)orally activePYR-resistantanti-malariaPlasmodium falciparumInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks