2. Immunology/Inflammation
  3. STING
  4. diABZI-V/C-DBCO

diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC50 values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC50 values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research.

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diABZI-V/C-DBCO Chemical Structure

diABZI-V/C-DBCO Chemical Structure

CAS No. : 3035557-60-6

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Based on 1 publication(s) in Google Scholar

diABZI-V/C-DBCO Related Antibodies

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Description

diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC50 values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC50 values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research[1].

Molecular Weight

1500.66

Formula

C78H89N19O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCN1N=C(C=C1C(NC2=NC3=C(N2C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=CC(C(N)=O)=CC(OC)=C64)C(OCCCNC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@H](C(C)C)NC(CCCCC(N8CC9=C(C=CC=C9)C#CC%10=C8C=CC=C%10)=O)=O)=O)CCCNC(N)=O)=O)=O)=CC(C(N)=O)=C3)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (66.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6664 mL 3.3319 mL 6.6637 mL
5 mM 0.1333 mL 0.6664 mL 1.3327 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6664 mL 3.3319 mL 6.6637 mL 16.6593 mL
5 mM 0.1333 mL 0.6664 mL 1.3327 mL 3.3319 mL
10 mM 0.0666 mL 0.3332 mL 0.6664 mL 1.6659 mL
15 mM 0.0444 mL 0.2221 mL 0.4442 mL 1.1106 mL
20 mM 0.0333 mL 0.1666 mL 0.3332 mL 0.8330 mL
25 mM 0.0267 mL 0.1333 mL 0.2665 mL 0.6664 mL
30 mM 0.0222 mL 0.1111 mL 0.2221 mL 0.5553 mL
40 mM 0.0167 mL 0.0833 mL 0.1666 mL 0.4165 mL
50 mM 0.0133 mL 0.0666 mL 0.1333 mL 0.3332 mL
60 mM 0.0111 mL 0.0555 mL 0.1111 mL 0.2777 mL
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diABZI-V/C-DBCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

diABZI-V/C-DBCO3035557-60-6STINGStimulator of Interferon GenesTMEM173MITAERISMPYSAnti-cancerInhibitorinhibitorinhibit

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