Diazo Biotin-PEG3-alkyne

Name: Diazo Biotin-PEG3-alkyne
Brand: MedChemExpress
SKU: HY-140925
Rating: 4.5 (1 reviews)

Cat. No.: HY-140925 Purity: 95.24%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Diazo Biotin-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diazo Biotin-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Diazo Biotin-PEG3-alkyne Chemical Structure

CAS No. : 1884349-58-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Diazo Biotin-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Diazo Biotin-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

795.94

Formula

C₃₉H₅₃N₇O₉S

CAS No.

1884349-58-9

Appearance

Solid

Color

Orange to reddish brown

SMILES

O=C(NCCOCCOCCOCCNC(C1=CC=C(/N=N/C2=CC(CCNC(CCOCC#C)=O)=CC=C2O)C=C1)=O)CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (157.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2564 mL	6.2819 mL	12.5638 mL
5 mM	0.2513 mL	1.2564 mL	2.5128 mL
10 mM	0.1256 mL	0.6282 mL	1.2564 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.24%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (242 KB) HNMR (174 KB) RP-HPLC (247 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2564 mL	6.2819 mL	12.5638 mL	31.4094 mL
	5 mM	0.2513 mL	1.2564 mL	2.5128 mL	6.2819 mL
	10 mM	0.1256 mL	0.6282 mL	1.2564 mL	3.1409 mL
	15 mM	0.0838 mL	0.4188 mL	0.8376 mL	2.0940 mL
	20 mM	0.0628 mL	0.3141 mL	0.6282 mL	1.5705 mL
	25 mM	0.0503 mL	0.2513 mL	0.5026 mL	1.2564 mL
	30 mM	0.0419 mL	0.2094 mL	0.4188 mL	1.0470 mL
	40 mM	0.0314 mL	0.1570 mL	0.3141 mL	0.7852 mL
	50 mM	0.0251 mL	0.1256 mL	0.2513 mL	0.6282 mL
	60 mM	0.0209 mL	0.1047 mL	0.2094 mL	0.5235 mL
	80 mM	0.0157 mL	0.0785 mL	0.1570 mL	0.3926 mL
	100 mM	0.0126 mL	0.0628 mL	0.1256 mL	0.3141 mL