Diazo Biotin-PEG3-azide

Name: Diazo Biotin-PEG3-azide
Brand: MedChemExpress
SKU: HY-140918
Rating: 4.5 (1 reviews)

Cat. No.: HY-140918 Purity: 95.46%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diazo Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Diazo Biotin-PEG3-azide Chemical Structure

CAS No. : 1339202-33-3

Size	Price	Stock	Quantity
5 mg	USD 330	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 510	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 910	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Diazo Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

711.83

Formula

C₃₃H₄₅N₉O₇S

CAS No.

1339202-33-3

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(NCCOCCOCCOCCNC(C1=CC=C(/N=N/C2=CC(CCN=[N+]=[N-])=CC=C2O)C=C1)=O)CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (175.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4048 mL	7.0241 mL	14.0483 mL
5 mM	0.2810 mL	1.4048 mL	2.8097 mL
10 mM	0.1405 mL	0.7024 mL	1.4048 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.46%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (242 KB) HNMR (145 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4048 mL	7.0241 mL	14.0483 mL	35.1207 mL
	5 mM	0.2810 mL	1.4048 mL	2.8097 mL	7.0241 mL
	10 mM	0.1405 mL	0.7024 mL	1.4048 mL	3.5121 mL
	15 mM	0.0937 mL	0.4683 mL	0.9366 mL	2.3414 mL
	20 mM	0.0702 mL	0.3512 mL	0.7024 mL	1.7560 mL
	25 mM	0.0562 mL	0.2810 mL	0.5619 mL	1.4048 mL
	30 mM	0.0468 mL	0.2341 mL	0.4683 mL	1.1707 mL
	40 mM	0.0351 mL	0.1756 mL	0.3512 mL	0.8780 mL
	50 mM	0.0281 mL	0.1405 mL	0.2810 mL	0.7024 mL
	60 mM	0.0234 mL	0.1171 mL	0.2341 mL	0.5853 mL
	80 mM	0.0176 mL	0.0878 mL	0.1756 mL	0.4390 mL
	100 mM	0.0140 mL	0.0702 mL	0.1405 mL	0.3512 mL