2. PROTAC
  3. PROTAC Linkers
  4. Diazo Biotin-PEG3-azide

Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diazo Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Diazo Biotin-PEG3-azide Chemical Structure

Diazo Biotin-PEG3-azide Chemical Structure

CAS No. : 1339202-33-3

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5 mg USD 330 In-stock
10 mg USD 510 In-stock
25 mg USD 910 In-stock
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Based on 1 publication(s) in Google Scholar

Diazo Biotin-PEG3-azide Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Diazo Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diazo Biotin-PEG3-azide Related Antibodies
Molecular Weight

711.83

Formula

C33H45N9O7S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(NCCOCCOCCOCCNC(C1=CC=C(/N=N/C2=CC(CCN=[N+]=[N-])=CC=C2O)C=C1)=O)CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (175.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4048 mL 7.0241 mL 14.0483 mL
5 mM 0.2810 mL 1.4048 mL 2.8097 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4048 mL 7.0241 mL 14.0483 mL 35.1207 mL
5 mM 0.2810 mL 1.4048 mL 2.8097 mL 7.0241 mL
10 mM 0.1405 mL 0.7024 mL 1.4048 mL 3.5121 mL
15 mM 0.0937 mL 0.4683 mL 0.9366 mL 2.3414 mL
20 mM 0.0702 mL 0.3512 mL 0.7024 mL 1.7560 mL
25 mM 0.0562 mL 0.2810 mL 0.5619 mL 1.4048 mL
30 mM 0.0468 mL 0.2341 mL 0.4683 mL 1.1707 mL
40 mM 0.0351 mL 0.1756 mL 0.3512 mL 0.8780 mL
50 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7024 mL
60 mM 0.0234 mL 0.1171 mL 0.2341 mL 0.5853 mL
80 mM 0.0176 mL 0.0878 mL 0.1756 mL 0.4390 mL
100 mM 0.0140 mL 0.0702 mL 0.1405 mL 0.3512 mL
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Diazo Biotin-PEG3-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diazo Biotin-PEG3-azide1339202-33-3PROTAC LinkersInhibitorinhibitorinhibit

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