Dicloxacillin sodium

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Data Sheet Handling Instructions

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Dicloxacillin sodium is a β-lactam antibiotic of the penicillin family. Dicloxacillin sodium against Gram-positive bacteria. Dicloxacillin sodium is active against β-lactamase-producing organisms such as Staphylococcus aureus.

For research use only. We do not sell to patients.

Dicloxacillin sodium Chemical Structure

CAS No. : 343-55-5

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Other In-stock Forms of Dicloxacillin sodium:

Dicloxacillin Sodium hydrate

Other Forms of Dicloxacillin sodium:

Dicloxacillin Sodium hydrate In-stock
Dicloxacillin-13C4 sodium hydrate Get quote
Dicloxacillin Get quote

2 Publications Citing Use of MCE Dicloxacillin sodium

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

β-lactam

In Vitro

Dicloxacillin exhibits EC₅₀ values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)^[3].
Dosage:	125 mg/kg.
Administration:	IV injection, single doses.
Result:	All the mice survived.

Clinical Trial

Molecular Weight

492.31

Formula

C₁₉H₁₆Cl₂N₃NaO₅S

CAS No.

343-55-5

SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25. [Content Brief]

[2]. Anne Sandberg, et al. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrob Agents Chemother. 2010 Jun;54(6):2391-400. [Content Brief]

[3]. John Chu, et al. Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol. 2016 Dec;12(12):1004-1006. [Content Brief]