Dihydrocubebin (Synonyms: (-)-Dihydrocubebin)

Cat. No.: HY-N10421: FAQs
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Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4).

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Dihydrocubebin Chemical Structure

CAS No. : 24563-03-9

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Description

Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BC	IC₅₀	> 5 μg/mL Compound: dihydrocubebin	Cytotoxicity against human BC cells by colorimetric method Cytotoxicity against human BC cells by colorimetric method	[PMID: 16038539]
KB	IC₅₀	> 5 μg/mL Compound: dihydrocubebin	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 16038539]
MCF7	IC₅₀	89.4 μM Compound: 9	Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs	[PMID: 20954722]
NCI-H187	IC₅₀	> 5 μg/mL Compound: dihydrocubebin	Cytotoxicity against human NCI-H187 cells by colorimetric method Cytotoxicity against human NCI-H187 cells by colorimetric method	[PMID: 16038539]
Vero	IC₅₀	83.8 μM Compound: 9	Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs	[PMID: 20954722]

Molecular Weight

358.39

Formula

C₂₀H₂₂O₆

CAS No.

24563-03-9

SMILES

OC[C@H](CC1=CC=C(OCO2)C2=C1)[C@H](CO)CC3=CC=C(OCO4)C4=C3

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Usia T, et al. Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: mechanism-based inhibition. Life Sci. 2005;76(20):2381-2391. [Content Brief]

Dihydrocubebin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrocubebin24563-03-9(-)-DihydrocubebinOthersPiper cubebaCYP3A4Inhibitorinhibitorinhibit

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