Dihydrocytochalasin B

Cat. No.: HY-N6701 Purity: 94.86%: FAQs
Data Sheet SDS COA Handling Instructions

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Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca²⁺increase in the mucosal scrapings.

For research use only. We do not sell to patients.

Dihydrocytochalasin B Chemical Structure

CAS No. : 39156-67-7

Size	Price	Stock	Quantity
500 μg	USD 182	In-stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport^[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis^[2]. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca²⁺increase in the mucosal scrapings^[3].

Molecular Weight

481.62

Formula

C₂₉H₃₉NO₅

CAS No.

39156-67-7

Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2(O3)[C@]([C@@H](C([C@@H](O)[C@]2([H])/C=C/C[C@@H](CCC[C@@H](O)CCC3=O)C)=C)C)([H])[C@H](CC4=CC=CC=C4)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : 30 mg/mL (62.29 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0763 mL	10.3816 mL	20.7633 mL
5 mM	0.4153 mL	2.0763 mL	4.1527 mL
10 mM	0.2076 mL	1.0382 mL	2.0763 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 94.86%

Select Batch:

Data Sheet (274 KB) SDS (584 KB)

COA (253 KB) RP-HPLC (263 KB)

Handling Instructions (2659 KB)

References

[1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70. [Content Brief]

[2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51. [Content Brief]

[3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF	1 mM	2.0763 mL	10.3816 mL	20.7633 mL	51.9081 mL
	5 mM	0.4153 mL	2.0763 mL	4.1527 mL	10.3816 mL
	10 mM	0.2076 mL	1.0382 mL	2.0763 mL	5.1908 mL
	15 mM	0.1384 mL	0.6921 mL	1.3842 mL	3.4605 mL
	20 mM	0.1038 mL	0.5191 mL	1.0382 mL	2.5954 mL
	25 mM	0.0831 mL	0.4153 mL	0.8305 mL	2.0763 mL
	30 mM	0.0692 mL	0.3461 mL	0.6921 mL	1.7303 mL
	40 mM	0.0519 mL	0.2595 mL	0.5191 mL	1.2977 mL
	50 mM	0.0415 mL	0.2076 mL	0.4153 mL	1.0382 mL
	60 mM	0.0346 mL	0.1730 mL	0.3461 mL	0.8651 mL