2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. Dimethyl-F-OICR-9429-COOH

Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Dimethyl-F-OICR-9429-COOH Chemical Structure

Dimethyl-F-OICR-9429-COOH Chemical Structure

CAS No. : 2407458-49-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 481 In-stock
Solution
10 mM * 1 mL in DMSO USD 481 In-stock
Solid
1 mg USD 160 In-stock
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1350 In-stock
50 mg USD 2200 In-stock
100 mg USD 3400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Dimethyl-F-OICR-9429-COOH Related Antibodies

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Description

Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs[1].

IC50 & Target

Ligand for Target Protein for PROTAC[1]
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethyl-F-OICR-9429-COOH Related Antibodies
Molecular Weight

546.51

Formula

C27H26F4N4O4
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@@H](N([C@@H](C3)C)C)C)C=CC(C4=CC(C(O)=O)=CC=C4F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (365.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8298 mL 9.1490 mL 18.2979 mL
5 mM 0.3660 mL 1.8298 mL 3.6596 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8298 mL 9.1490 mL 18.2979 mL 45.7448 mL
5 mM 0.3660 mL 1.8298 mL 3.6596 mL 9.1490 mL
10 mM 0.1830 mL 0.9149 mL 1.8298 mL 4.5745 mL
15 mM 0.1220 mL 0.6099 mL 1.2199 mL 3.0497 mL
20 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
25 mM 0.0732 mL 0.3660 mL 0.7319 mL 1.8298 mL
30 mM 0.0610 mL 0.3050 mL 0.6099 mL 1.5248 mL
40 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1436 mL
50 mM 0.0366 mL 0.1830 mL 0.3660 mL 0.9149 mL
60 mM 0.0305 mL 0.1525 mL 0.3050 mL 0.7624 mL
80 mM 0.0229 mL 0.1144 mL 0.2287 mL 0.5718 mL
100 mM 0.0183 mL 0.0915 mL 0.1830 mL 0.4574 mL
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Dimethyl-F-OICR-9429-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl-F-OICR-9429-COOH2407458-49-3Ligands for Target Protein for PROTACTarget Protein-binding MoietyWD40repeatdomainWDR5Inhibitorinhibitorinhibit

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