2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Dimethyl lithospermate B

Dimethyl lithospermate B  (Synonyms: dmLSB)

Cat. No.: HY-N6868 Purity: 98.85%
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Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP).

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Dimethyl lithospermate B Chemical Structure

Dimethyl lithospermate B Chemical Structure

CAS No. : 875313-64-7

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1 mg USD 220 In-stock
5 mg USD 580 In-stock
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Dimethyl lithospermate B Related Antibodies

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Description

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2].

IC50 & Target

Na+ channel[1]
Molecular Weight

746.67

Formula

C38H34O16
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=CC(C[C@H](C(OC)=O)OC([C@H]2C3=C(/C=C/C(O[C@@H](C(OC)=O)CC4=CC(O)=C(O)C=C4)=O)C=CC(O)=C3O[C@@H]2C5=CC(O)=C(O)C=C5)=O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (133.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3393 mL 6.6964 mL 13.3928 mL
5 mM 0.2679 mL 1.3393 mL 2.6786 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3393 mL 6.6964 mL 13.3928 mL 33.4820 mL
5 mM 0.2679 mL 1.3393 mL 2.6786 mL 6.6964 mL
10 mM 0.1339 mL 0.6696 mL 1.3393 mL 3.3482 mL
15 mM 0.0893 mL 0.4464 mL 0.8929 mL 2.2321 mL
20 mM 0.0670 mL 0.3348 mL 0.6696 mL 1.6741 mL
25 mM 0.0536 mL 0.2679 mL 0.5357 mL 1.3393 mL
30 mM 0.0446 mL 0.2232 mL 0.4464 mL 1.1161 mL
40 mM 0.0335 mL 0.1674 mL 0.3348 mL 0.8370 mL
50 mM 0.0268 mL 0.1339 mL 0.2679 mL 0.6696 mL
60 mM 0.0223 mL 0.1116 mL 0.2232 mL 0.5580 mL
80 mM 0.0167 mL 0.0837 mL 0.1674 mL 0.4185 mL
100 mM 0.0134 mL 0.0670 mL 0.1339 mL 0.3348 mL
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Dimethyl lithospermate B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl lithospermate B875313-64-7dmLSBSodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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