2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Diprovocim-X

Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the adaptive immune response.

For research use only. We do not sell to patients.

Diprovocim-X Chemical Structure

Diprovocim-X Chemical Structure

CAS No. : 3005274-77-8

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1 mg USD 720 In-stock
5 mg USD 1800 In-stock
10 mg USD 2880 In-stock
25 mg USD 5760 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Diprovocim-X Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the adaptive immune response[1].

IC50 & Target

TLR1

 

TLR2

 

In Vitro

Diprovocim-X stimulates release of TNF-α from (human) differentiated THP-1 cells proves dependent on both TLR2 and TLR1, but notably independent of TLR6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diprovocim-X Related Antibodies
Molecular Weight

1134.41

Formula

C66H83N7O10
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OCCCCCCCCCCCCNC([C@@H]1CN(C(C2=CC=C(C(N3C[C@@H](C(N[C@@H]4[C@@H](C5=CC=CC=C5)C4)=O)[C@H](C(N[C@@H]6[C@@H](C7=CC=CC=C7)C6)=O)C3)=O)C=C2)=O)C[C@H]1C(N[C@@H]8[C@@H](C9=CC=CC=C9)C8)=O)=O)CNC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (44.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8815 mL 4.4076 mL 8.8152 mL
5 mM 0.1763 mL 0.8815 mL 1.7630 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.64%

COA (246 KB) HNMR (148 KB) RP-HPLC (171 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8815 mL 4.4076 mL 8.8152 mL 22.0379 mL
5 mM 0.1763 mL 0.8815 mL 1.7630 mL 4.4076 mL
10 mM 0.0882 mL 0.4408 mL 0.8815 mL 2.2038 mL
15 mM 0.0588 mL 0.2938 mL 0.5877 mL 1.4692 mL
20 mM 0.0441 mL 0.2204 mL 0.4408 mL 1.1019 mL
25 mM 0.0353 mL 0.1763 mL 0.3526 mL 0.8815 mL
30 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7346 mL
40 mM 0.0220 mL 0.1102 mL 0.2204 mL 0.5509 mL
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Diprovocim-X Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diprovocim-X3005274-77-8Toll-like Receptor (TLR)THP-1 cellsTNF-αadjuvantimmuneInhibitorinhibitorinhibit

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