Dipyridamole-d₂₀

Cat. No.: HY-B0312S: FAQs
Data Sheet SDS COA Handling Instructions

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Dipyridamole-d₂₀ is the deuterium labeled Dipyridamole. Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells[1][2][3].

For research use only. We do not sell to patients.

Dipyridamole-d<sub>20</sub> Chemical Structure

Dipyridamole-d₂₀ Chemical Structure

CAS No. : 1189983-52-5

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1 mg	USD 690	Ask For Quote & Lead Time

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Other Forms of Dipyridamole-d₂₀:

Dipyridamole In-stock

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•Related Small Molecules:

•Related Proteins:

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

524.75

Formula

C₂₄H₂₀D₂₀N₈O₄

CAS No.

1189983-52-5

Unlabeled CAS

58-32-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

N(CCO)(CCO)C1=NC2=C(C(=N1)N3C(C(C(C(C3([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])N=C(N(CCO)CCO)N=C2N4C(C(C(C(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (95.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.67 mg/mL (1.28 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9057 mL	9.5283 mL	19.0567 mL
5 mM	0.3811 mL	1.9057 mL	3.8113 mL
10 mM	0.1906 mL	0.9528 mL	1.9057 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (283 KB) SDS (251 KB)

COA (262 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Klabunde, R.E., Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol, 1983. 93(1-2): p. 21-6. [Content Brief]

[3]. Best, L.C., et al., Mode of action of dipyridamole on human platelets. Thromb Res, 1979. 16(3-4): p. 367-79. [Content Brief]

[4]. Aktas, B., et al., Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke, 2003. 34(3): p. 764-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO / DMSO	1 mM	1.9057 mL	9.5283 mL	19.0567 mL	47.6417 mL
DMSO / DMSO	5 mM	0.3811 mL	1.9057 mL	3.8113 mL	9.5283 mL
	10 mM	0.1906 mL	0.9528 mL	1.9057 mL	4.7642 mL
	15 mM	0.1270 mL	0.6352 mL	1.2704 mL	3.1761 mL
	20 mM	0.0953 mL	0.4764 mL	0.9528 mL	2.3821 mL
	25 mM	0.0762 mL	0.3811 mL	0.7623 mL	1.9057 mL
	30 mM	0.0635 mL	0.3176 mL	0.6352 mL	1.5881 mL
	40 mM	0.0476 mL	0.2382 mL	0.4764 mL	1.1910 mL
	50 mM	0.0381 mL	0.1906 mL	0.3811 mL	0.9528 mL
	60 mM	0.0318 mL	0.1588 mL	0.3176 mL	0.7940 mL
	80 mM	0.0238 mL	0.1191 mL	0.2382 mL	0.5955 mL