DL-AP5 lithium (Synonyms: 2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium)

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DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina.

For research use only. We do not sell to patients.

DL-AP5 lithium Chemical Structure

CAS No. : 125229-62-1

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Other In-stock Forms of DL-AP5 lithium:

D-AP5

Other Forms of DL-AP5 lithium:

D-AP5 In-stock
L-AP5 Get quote
DL-AP5 Get quote
DL-AP5 sodium Get quote

17 Publications Citing Use of MCE DL-AP5 lithium

: DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2022 Nov 15. [Abstract]; Treatment with the AMDAR inhibitor (NBQX) and NMDAR inhibitor (D-AP5) effectively reduce the expression of NMDAR (NR1, NR2A/2B) and AMPAR (GluA1, GluA2) in PFC, respectively.

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

IC₅₀ & Target

NMDA Receptor

In Vitro

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels^[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA^[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption^[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-230 g)^[3]
Dosage:	1, 3.2 and 10 μg/rat
Administration:	Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result:	Significantly decreased the effect of NMDA (10^-2 μg/rat, intra-CA1) with significant interaction.

Animal Model:	Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:	0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration:	Intracerebroventricular injection
Result:	Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.

Animal Model:	Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:	5 nmol
Administration:	Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result:	Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.

Molecular Weight

203.06

Formula

C₅H₁₁LiNO₅P

CAS No.

125229-62-1

SMILES

NC(CCCP(O)(O)=O)C(O[Li])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]

[2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]

[3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]

[4]. Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. [Content Brief]

[5]. Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. [Content Brief]

DL-AP5 lithium Related Classifications

Neurological Disease Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-AP5125229-62-12-APVDL-2-Amino-5-phosphonovaleric acidiGluRIonotropic glutamate receptorsAntinociceptive activityTonic painGanglion cellsRetinaArc/Arg3.1Glutamate receptorInhibitorinhibitorinhibit

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