DL-AP5 sodium (Synonyms: 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium)

Name: DL-AP5 sodium
Brand: MedChemExpress
SKU: HY-100714C
Rating: 5.0 (18 reviews)

Cat. No.: HY-100714C Purity: 99.20%: FAQs
Data Sheet SDS COA Handling Instructions

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DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina.

For research use only. We do not sell to patients.

DL-AP5 sodium Chemical Structure

CAS No. : 1303993-72-7

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1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
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Based on 18 publication(s) in Google Scholar

Other Forms of DL-AP5 sodium:

D-AP5 In-stock
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17 Publications Citing Use of MCE DL-AP5 sodium

: DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2022 Nov 15. [Abstract]; Treatment with the AMDAR inhibitor (NBQX) and NMDAR inhibitor (D-AP5) effectively reduce the expression of NMDAR (NR1, NR2A/2B) and AMPAR (GluA1, GluA2) in PFC, respectively.

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Description

IC₅₀ & Target

NMDA Receptor

In Vitro

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels^[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA^[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption^[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-230 g)^[3]
Dosage:	1, 3.2 and 10 μg/rat
Administration:	Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result:	Significantly decreased the effect of NMDA (10^-2 μg/rat, intra-CA1) with significant interaction.

Animal Model:	Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:	0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration:	Intracerebroventricular injection
Result:	Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.

Animal Model:	Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:	5 nmol
Administration:	Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result:	Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.

Molecular Weight

219.11

Formula

C₅H₁₁NNaO₅P

CAS No.

1303993-72-7

Appearance

Solid

Color

White to off-white

SMILES

NC(CCCP(O)(O)=O)C(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.20%

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Data Sheet (272 KB) SDS (252 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]

[2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]

[3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]

[4]. Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. [Content Brief]

[5]. Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. [Content Brief]

DL-AP5 sodium Related Classifications

Neurological Disease Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-AP51303993-72-72-APVDL-2-Amino-5-phosphonovaleric acidiGluRIonotropic glutamate receptorsAntinociceptive activityTonic painGanglion cellsRetinaArc/Arg3.1Glutamate receptorInhibitorinhibitorinhibit

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DL-AP5 sodium (Synonyms: 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium)

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17 Publications Citing Use of MCE DL-AP5 sodium

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