1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. DL-Gabaculine hydrochloride

DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked γ-aminobutyric acid-α-ketoglutaric acid transaminase with a Ki of 2.86 μM.

For research use only. We do not sell to patients.

DL-Gabaculine hydrochloride Chemical Structure

DL-Gabaculine hydrochloride Chemical Structure

CAS No. : 59556-17-1

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Description

DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked γ-aminobutyric acid-α-ketoglutaric acid transaminase with a Ki of 2.86 μM[1].

IC50 & Target

γ-aminobutyric acid-α-ketoglutaric acid transaminase[1]

Molecular Weight

175.61

Formula

C7H10ClNO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(N)C1)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (113.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6944 mL 28.4722 mL 56.9444 mL
5 mM 1.1389 mL 5.6944 mL 11.3889 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6944 mL 28.4722 mL 56.9444 mL 142.3609 mL
5 mM 1.1389 mL 5.6944 mL 11.3889 mL 28.4722 mL
10 mM 0.5694 mL 2.8472 mL 5.6944 mL 14.2361 mL
15 mM 0.3796 mL 1.8981 mL 3.7963 mL 9.4907 mL
20 mM 0.2847 mL 1.4236 mL 2.8472 mL 7.1180 mL
25 mM 0.2278 mL 1.1389 mL 2.2778 mL 5.6944 mL
30 mM 0.1898 mL 0.9491 mL 1.8981 mL 4.7454 mL
40 mM 0.1424 mL 0.7118 mL 1.4236 mL 3.5590 mL
50 mM 0.1139 mL 0.5694 mL 1.1389 mL 2.8472 mL
60 mM 0.0949 mL 0.4745 mL 0.9491 mL 2.3727 mL
80 mM 0.0712 mL 0.3559 mL 0.7118 mL 1.7795 mL
100 mM 0.0569 mL 0.2847 mL 0.5694 mL 1.4236 mL
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DL-Gabaculine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DL-Gabaculine hydrochloride
Cat. No.:
HY-15377
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