DL-Gabaculine hydrochloride

Cat. No.: HY-15377 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked γ-aminobutyric acid-α-ketoglutaric acid transaminase with a K_i of 2.86 μM.

For research use only. We do not sell to patients.

DL-Gabaculine hydrochloride Chemical Structure

CAS No. : 59556-17-1

Size	Price	Stock	Quantity
1 mg	USD 103	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Description

DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked γ-aminobutyric acid-α-ketoglutaric acid transaminase with a K_i of 2.86 μM^[1].

IC₅₀ & Target

γ-aminobutyric acid-α-ketoglutaric acid transaminase^[1]

Molecular Weight

175.61

Formula

C₇H₁₀ClNO₂

CAS No.

59556-17-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(N)C1)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 20 mg/mL (113.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6944 mL	28.4722 mL	56.9444 mL
5 mM	1.1389 mL	5.6944 mL	11.3889 mL
10 mM	0.5694 mL	2.8472 mL	5.6944 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Rando R R. Mechanism of the irreversible inhibition of γ-aminobutyric acid-α-ketoglutaric acid transaminase by the neurotoxin gabaculine. Biochemistry, 1977, 16(21): 4604-4610.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.6944 mL	28.4722 mL	56.9444 mL	142.3609 mL
	5 mM	1.1389 mL	5.6944 mL	11.3889 mL	28.4722 mL
	10 mM	0.5694 mL	2.8472 mL	5.6944 mL	14.2361 mL
	15 mM	0.3796 mL	1.8981 mL	3.7963 mL	9.4907 mL
	20 mM	0.2847 mL	1.4236 mL	2.8472 mL	7.1180 mL
	25 mM	0.2278 mL	1.1389 mL	2.2778 mL	5.6944 mL
	30 mM	0.1898 mL	0.9491 mL	1.8981 mL	4.7454 mL
	40 mM	0.1424 mL	0.7118 mL	1.4236 mL	3.5590 mL
	50 mM	0.1139 mL	0.5694 mL	1.1389 mL	2.8472 mL
	60 mM	0.0949 mL	0.4745 mL	0.9491 mL	2.3727 mL
	80 mM	0.0712 mL	0.3559 mL	0.7118 mL	1.7795 mL
	100 mM	0.0569 mL	0.2847 mL	0.5694 mL	1.4236 mL