2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. DL-β-Hydroxybutyryl coenzyme A lithium

DL-β-Hydroxybutyryl coenzyme A lithium 

Cat. No.: HY-134426 Purity: 98.00%
SDS COA Handling Instructions

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DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase.

For research use only. We do not sell to patients.

DL-β-Hydroxybutyryl coenzyme A lithium Chemical Structure

DL-β-Hydroxybutyryl coenzyme A lithium Chemical Structure

CAS No. : 103404-51-9

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Based on 1 publication(s) in Google Scholar

Other Forms of DL-β-Hydroxybutyryl coenzyme A lithium:

DL-β-Hydroxybutyryl coenzyme A lithium Related Antibodies

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Description

DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase[1][2].

In Vitro

DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can be produced as an intermediate metabolite via the mitochondrial pathway, where impaired mitochondrial function in cancer cells leads to the accumulation of it. At the same time, DL-β-Hydroxybutyryl coenzyme A lithium can also be produced via the fatty acid β-oxidation, which is accelerated by starvation and fasting, leading to the accumulation of it and thus to diseases caused by certain metabolic adaptations[1].
DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can act as a cofactor for lysine β-hydroxybutyrylation (Kbhb), with elevated levels of histone Kbhb in a streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-β-Hydroxybutyryl coenzyme A lithium Related Antibodies
Molecular Weight

874.45

Formula

C25H42Li3N7O18P3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(CC(C)O)=O)=O)=O)O)C)=O)=O)O3.[Li].[Li].[Li]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (57.18 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1436 mL 5.7179 mL 11.4358 mL
5 mM 0.2287 mL 1.1436 mL 2.2872 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.00%

SDS (252 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1436 mL 5.7179 mL 11.4358 mL 28.5894 mL
5 mM 0.2287 mL 1.1436 mL 2.2872 mL 5.7179 mL
10 mM 0.1144 mL 0.5718 mL 1.1436 mL 2.8589 mL
15 mM 0.0762 mL 0.3812 mL 0.7624 mL 1.9060 mL
20 mM 0.0572 mL 0.2859 mL 0.5718 mL 1.4295 mL
25 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1436 mL
30 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.9530 mL
40 mM 0.0286 mL 0.1429 mL 0.2859 mL 0.7147 mL
50 mM 0.0229 mL 0.1144 mL 0.2287 mL 0.5718 mL
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DL-β-Hydroxybutyryl coenzyme A lithium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-β-Hydroxybutyryl coenzyme A103404-51-9Endogenous Metabolitecoenzyme Aβ-hydroxybutyric acidbutyric acidlysinetryptophanintermediateInhibitorinhibitorinhibit

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