2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. DNA relaxation-IN-1

DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 (DNA Lig1) inhibitor, which inhibits DNA ligation and disrupts Lig I’s DNA relaxation activity. DNA relaxation-IN-1 combined with Topotecan (HY-13768) exhibits a synergistic antiproliferative effect on colorectal cancer cells.

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DNA relaxation-IN-1 Chemical Structure

DNA relaxation-IN-1 Chemical Structure

CAS No. : 2190506-29-5

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DNA relaxation-IN-1 Related Antibodies

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Description

DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 (DNA Lig1) inhibitor, which inhibits DNA ligation and disrupts Lig I’s DNA relaxation activity. DNA relaxation-IN-1 combined with Topotecan (HY-13768) exhibits a synergistic antiproliferative effect on colorectal cancer cells[1].

Molecular Weight

493.62

Formula

C30H27N3O2S
CAS No.
SMILES

O=C(C1=CC=CS1)/C=C/C2=CC(C(C3=C(C)NC4=C3C=CC=C4)C(C#N)=C(N)O5)=C5C(C(C)(C)C)=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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DNA relaxation-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNA relaxation-IN-12190506-29-5DNA/RNA SynthesisDNA Ligase 1TopotecanDNA relaxationcolorectal cancerantiproliferativeInhibitorinhibitorinhibit

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