DNA relaxation-IN-1

Cat. No.: HY-161152 Purity: 98.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 (DNA Lig1) inhibitor, which inhibits DNA ligation and disrupts Lig I’s DNA relaxation activity. DNA relaxation-IN-1 combined with Topotecan (HY-13768) exhibits a synergistic antiproliferative effect on colorectal cancer cells.

For research use only. We do not sell to patients.

DNA relaxation-IN-1 Chemical Structure

CAS No. : 2190506-29-5

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 920	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1480	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

493.62

Formula

C₃₀H₂₇N₃O₂S

CAS No.

2190506-29-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CS1)/C=C/C2=CC(C(C3=C(C)NC4=C3C=CC=C4)C(C#N)=C(N)O5)=C5C(C(C)(C)C)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (202.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0258 mL	10.1292 mL	20.2585 mL
5 mM	0.4052 mL	2.0258 mL	4.0517 mL
10 mM	0.2026 mL	1.0129 mL	2.0258 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.37%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (261 KB) HNMR (267 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Maurya P, et al. Synergy between human DNA ligase I and topoisomerase 1 unveils new therapeutic strategy for the management of colorectal cancer. J Biomol Struct Dyn. 2024 Jan 5:1-16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0258 mL	10.1292 mL	20.2585 mL	50.6462 mL
	5 mM	0.4052 mL	2.0258 mL	4.0517 mL	10.1292 mL
	10 mM	0.2026 mL	1.0129 mL	2.0258 mL	5.0646 mL
	15 mM	0.1351 mL	0.6753 mL	1.3506 mL	3.3764 mL
	20 mM	0.1013 mL	0.5065 mL	1.0129 mL	2.5323 mL
	25 mM	0.0810 mL	0.4052 mL	0.8103 mL	2.0258 mL
	30 mM	0.0675 mL	0.3376 mL	0.6753 mL	1.6882 mL
	40 mM	0.0506 mL	0.2532 mL	0.5065 mL	1.2662 mL
	50 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0129 mL
	60 mM	0.0338 mL	0.1688 mL	0.3376 mL	0.8441 mL
	80 mM	0.0253 mL	0.1266 mL	0.2532 mL	0.6331 mL
	100 mM	0.0203 mL	0.1013 mL	0.2026 mL	0.5065 mL