Dopamine D2 receptor agonist-2

Cat. No.: HY-151515: FAQs
Data Sheet Handling Instructions

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Dopamine D2 receptor agonist-2 (compound 36) is a potent dopamine D₂ receptor biased agonism ligand with an K_i value of 11.2 nM. Dopamine D2 receptor agonist-2 can be used to research antipsychosis.

For research use only. We do not sell to patients.

Dopamine D2 receptor agonist-2 Chemical Structure

CAS No. : 1610591-93-9

Size	Price	Stock	Quantity
1 mg	USD 90	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

K_i: 11.2 nM (dopamine D₂ receptor)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.3 nM Compound: 36	Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated for 30 mins by AlphaScreen assay Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated for 30 mins by AlphaScreen assay	[PMID: 24827597]
CHO	EC₅₀	13.2 nM Compound: 36	Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as induction of ERK1/2 phosphorylation by AlphaScreen assay Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as induction of ERK1/2 phosphorylation by AlphaScreen assay	[PMID: 24827597]

Molecular Weight

520.52

Formula

C₂₅H₃₁Cl₂N₅OS

CAS No.

1610591-93-9

SMILES

O=C(C1=C(N)C2=C(C)C=C(C)N=C2S1)NCCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (192.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9212 mL	9.6058 mL	19.2116 mL
5 mM	0.3842 mL	1.9212 mL	3.8423 mL
10 mM	0.1921 mL	0.9606 mL	1.9212 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Szabo M, et al. Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D₂ receptor. J Med Chem. 2014 Jun 12;57(11):4924-39. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9212 mL	9.6058 mL	19.2116 mL	48.0289 mL
	5 mM	0.3842 mL	1.9212 mL	3.8423 mL	9.6058 mL
	10 mM	0.1921 mL	0.9606 mL	1.9212 mL	4.8029 mL
	15 mM	0.1281 mL	0.6404 mL	1.2808 mL	3.2019 mL
	20 mM	0.0961 mL	0.4803 mL	0.9606 mL	2.4014 mL
	25 mM	0.0768 mL	0.3842 mL	0.7685 mL	1.9212 mL
	30 mM	0.0640 mL	0.3202 mL	0.6404 mL	1.6010 mL
	40 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL
	50 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9606 mL
	60 mM	0.0320 mL	0.1601 mL	0.3202 mL	0.8005 mL
	80 mM	0.0240 mL	0.1201 mL	0.2401 mL	0.6004 mL
	100 mM	0.0192 mL	0.0961 mL	0.1921 mL	0.4803 mL