2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Dopamine D2 receptor agonist-3

Dopamine D2 receptor agonist-3 (compound 3) is a selective D2 receptor partial agonist and Dopamine D3 receptor antagonist (with pEC50 of 8.3 and <5.5 respectively).

For research use only. We do not sell to patients.

Dopamine D2 receptor agonist-3 Chemical Structure

Dopamine D2 receptor agonist-3 Chemical Structure

CAS No. : 1257326-24-1

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Dopamine D2 receptor agonist-3 Related Antibodies

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Description

Dopamine D2 receptor agonist-3 (compound 3) is a selective D2 receptor partial agonist and Dopamine D3 receptor antagonist (with pEC50 of 8.3 and <5.5 respectively)[1].

IC50 & Target[1]

D2 Receptor

5 nM (EC50)

D3 Receptor

>3.2 μM (EC50)

In Vivo

Dopamine D2 receptor agonist-3 (3 mg/kg, s.c.) shows high brain penetration (brain to blood ratio of 5.5) and Tmax of 0.5 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

295.81

Formula

C15H22ClN3O
CAS No.
Appearance

Solid

SMILES

O=C1N(CC2NCCCC2)CCN1C3=CC=CC=C3.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 3 mg/mL (10.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3805 mL 16.9027 mL 33.8055 mL
5 mM 0.6761 mL 3.3805 mL 6.7611 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3805 mL 16.9027 mL 33.8055 mL 84.5137 mL
5 mM 0.6761 mL 3.3805 mL 6.7611 mL 16.9027 mL
10 mM 0.3381 mL 1.6903 mL 3.3805 mL 8.4514 mL
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Dopamine D2 receptor agonist-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dopamine D2 receptor agonist-31257326-24-1Dopamine ReceptorDopaminepartial agonistInhibitorinhibitorinhibit

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