2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor 5-HT Receptor
  4. Dopamine D3 receptor ligand-5

Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with Ki values of 2.85 nM and 0.14 nM for D2R and D3R, respectively.

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Dopamine D3 receptor ligand-5 Chemical Structure

Dopamine D3 receptor ligand-5 Chemical Structure

CAS No. : 2899250-94-1

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Dopamine D3 receptor ligand-5 Related Antibodies

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Description

Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with Ki values of 2.85 nM and 0.14 nM for D2R and D3R, respectively[1].

IC50 & Target[1]

D3 Receptor

0.14 nM (Ki)

5-HT2B Receptor

1.47 nM (Ki)

D2 Receptor

2.85 nM (Ki)

5-HT1A Receptor

6 nM (Ki)

5-HT2A Receptor

54 nM (Ki)

5-HT2C Receptor

252 nM (Ki)

D4 Receptor

756 nM (Ki)

D1 Receptor

4600 nM (Ki)

In Vivo

Dopamine D3 receptor ligand-5 (13a) decreases cocaine self-administration (FR2; 1-10 mg/kg, i.p.) in rats, suggesting that partial agonists/antagonists with modest D3R/D2R-selectivity may be effective in treating PSUD and potentially comorbidities with other affective disorders[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

442.42

Formula

C22H33Cl2N3O2
CAS No.
SMILES

ClC1=C(C=CC=C1Cl)N2CCN(CC2)CC[C@@H]3CC[C@H](CC3)NC(CCOC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dopamine D3 receptor ligand-5 Related Classifications

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Help & FAQs
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Keywords:

Dopamine D3 receptor ligand-52899250-94-1Dopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorCariprazineD3RD2RPSUDDopamineInhibitorinhibitorinhibit

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