Doravirine-¹³C,d₃  (Synonyms: MK-1439-¹³C,d₃)

Doravirine-13C,d3 (MK-1439-13C,d3) is the deuterium labeled Doravirine (HY-16767). Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC₅₀s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively^[1].

429.76

C₁₆¹³CH₈D₃ClF₃N₅O₃

1338225-97-0

N#CC1=CC(OC2=C(C(F)(F)F)C=CN(CC(N3[13C]([2H])([2H])[2H])=NNC3=O)C2=O)=CC(Cl)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lai MT et al. In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2014;58(3):1652-63.  [Content Brief]

  [2]. Anderson MS et al. Safety, tolerability and pharmacokinetics of doravirine, a novel HIV non-nucleoside reverse transcriptase inhibitor, after single and multiple doses in healthy subjects. Antivir Ther. 2015;20(4):397-405.  [Content Brief]