2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. DOTA-GA(tBu)4

DOTA-GA(tBu)4 is a macrocyclic chelator used in medical imaging.

For research use only. We do not sell to patients.

DOTA-GA(tBu)4 Chemical Structure

DOTA-GA(tBu)4 Chemical Structure

CAS No. : 306776-79-4

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Based on 1 publication(s) in Google Scholar

DOTA-GA(tBu)4 Related Antibodies

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Description

DOTA-GA(tBu)4 is a macrocyclic chelator used in medical imaging[1].

IC50 & Target

RDC Bifunctional Chelator

 

Molecular Weight

700.90

Formula

C35H64N4O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC(N1CCN(CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)C(OC(C)(C)C)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (142.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4267 mL 7.1337 mL 14.2674 mL
5 mM 0.2853 mL 1.4267 mL 2.8535 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (254 KB) HNMR (292 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4267 mL 7.1337 mL 14.2674 mL 35.6684 mL
5 mM 0.2853 mL 1.4267 mL 2.8535 mL 7.1337 mL
10 mM 0.1427 mL 0.7134 mL 1.4267 mL 3.5668 mL
15 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3779 mL
20 mM 0.0713 mL 0.3567 mL 0.7134 mL 1.7834 mL
25 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.4267 mL
30 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1889 mL
40 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.8917 mL
50 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.7134 mL
60 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5945 mL
80 mM 0.0178 mL 0.0892 mL 0.1783 mL 0.4459 mL
100 mM 0.0143 mL 0.0713 mL 0.1427 mL 0.3567 mL
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DOTA-GA(tBu)4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-GA(tBu)4306776-79-4Radionuclide-Drug Conjugates (RDCs)Inhibitorinhibitorinhibit

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