RDC Bifunctional Chelator

RDC bifunctional chelators (BFC) serve two purposes: (1) to secure the radiometal ion and (2) to provide a covalent link between the complex and the targeting vector. BFCs are normally adapted from nonbifunctional analogues through the addition of pendant arms bearing a functional group available for facile bioconjugate coupling. DOTA and its derivatives are one of the most widely used bifunctional chelating agents.

RDC Bifunctional Chelator Related Products (58):

Cat. No.	Product Name	Effect	Purity

HY-W034551

DOTA-tri(t-butyl ester)		99.46%
DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging.

HY-W087027

Maleimide-NOTA		99.69%
Maleimide-NOTA is a chelator for the labeling of peptides and antibodies. Maleimide-NOTA can react with cysteine.

HY-W087028

NOTA-NHS ester
NOTA-NHS ester is a molecule related to radiolabeling drugs (RDC) that can be used for fluorescent labeling and radioactive nuclide labeling applications.

HY-W250574

NOTA-bis(tBu)ester
NOTA-bis(tBu)ester (NOTA-bis(t-Butyl ester)), a NOTA derivative, is a bifunctional chelator that can be used for drug coupling.

HY-136641

NOTA-FAPI		99.26%
NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI can be used as a probe for FAP-targeted tumour imaging. NOTA-FAPI has good tumour detection efficacy and excellent imaging quality.

HY-W087187

DOTAGA-anhydride
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.

HY-164589

NOPO
NOPO is a radionuclide conjugate (RDC), which is capable of binding to a radionuclide. RDC has the ability to specifically target biomolecules and can be used in medical imaging or therapy.

HY-157977

DOTA-GA-maleimide		99.26%
DOTA-GA-maleimide is a macrocyclic chelator, which forms stable complex with metals. DOTA-GA-maleimide is utilized as radiolabelled imaging agent.

HY-134418

NOTA		≥98.0%
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect.

HY-155483

PSMA-BCH		99.93%
PSMA-BCH (NOTA-PSMA) is a NOTA-conjugated precursor. NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools.

HY-100138

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)		≥98.0%
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a macrocycle DOTA derivative for tumor pretargeting.

HY-132989

Mal-Deferoxamine
Mal-Deferoxamine is a maleamide (Mal)-containing Deferoxamine (HY-B1625). Mal selectively covalently binds to sulfur groups to produce a linking reaction. Mal-Deferoxamine can be combined with radionuclides to synthesize radionuclide drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy..

HY-W539916

Azido-mono-amide-DOTA		99.96%
Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.

HY-W717743

DOTAM-mono-acid		≥98.0%
DOTAM-mono-acidis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-mono-acid can be used for conjugation of peptides and radionuclides.

HY-W614269

DOTA-GA(tBu)4		≥98.0%
DOTA-GA(tBu)4 is a macrocyclic chelator used in medical imaging.

HY-W782083

p-SCN-Bn-NOTA trihydrochloride		99.62%
p-SCN-Bn-NOTA (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. p-SCN-Bn-NOTA (trihydrochloride) can be used for conjugation of peptides and radionuclides.

HY-160607

MMA-NODAGA
MMA-NODAGA is a chelator for site-specific labeling of targeting proteins containing unpaired cysteine. MMA-NODAGA can be used to conjugate with exosome and ⁶⁴Cu in image with positron emission tomography (PET)^<[2].

HY-158067

Deferoxamine-DBCO
Deferoxamine-DBCOis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DFO derivative used for tumor pre-targeting. Deferoxamine-DBCO can be used for conjugation of peptides and radionuclides.

HY-W782078

Butyne-DOTA		≥98.0%
Butyne-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA can be used for conjugation of peptides and radionuclides.

HY-W749627

NO2A-Butyne		≥98.0%
NO2A-Butyneis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Butyne can be used for conjugation of peptides and radionuclides.

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