2. PROTAC
  3. PROTAC Linkers
  4. DOTA-PEG5-amine

DOTA-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

DOTA-PEG5-amine Chemical Structure

DOTA-PEG5-amine Chemical Structure

Size Price Stock Quantity
1 mg USD 248 In-stock
5 mg USD 620 In-stock
10 mg USD 890 In-stock
50 mg USD 2700 In-stock
100 mg USD 4350 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

DOTA-PEG5-amine Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

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Description

DOTA-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-PEG5-amine Related Antibodies
Molecular Weight

666.76

Formula

C28H54N6O12
Appearance

Solid

Color

White to off-white

SMILES

O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(NCCOCCOCCOCCOCCOCCN)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (74.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4998 mL 7.4990 mL 14.9979 mL
5 mM 0.3000 mL 1.4998 mL 2.9996 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4998 mL 7.4990 mL 14.9979 mL 37.4948 mL
5 mM 0.3000 mL 1.4998 mL 2.9996 mL 7.4990 mL
10 mM 0.1500 mL 0.7499 mL 1.4998 mL 3.7495 mL
15 mM 0.1000 mL 0.4999 mL 0.9999 mL 2.4997 mL
20 mM 0.0750 mL 0.3749 mL 0.7499 mL 1.8747 mL
25 mM 0.0600 mL 0.3000 mL 0.5999 mL 1.4998 mL
30 mM 0.0500 mL 0.2500 mL 0.4999 mL 1.2498 mL
40 mM 0.0375 mL 0.1875 mL 0.3749 mL 0.9374 mL
50 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7499 mL
60 mM 0.0250 mL 0.1250 mL 0.2500 mL 0.6249 mL
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DOTA-PEG5-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-PEG5-aminePROTAC LinkersInhibitorinhibitorinhibit

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