2. PROTAC
  3. PROTAC Linkers
  4. DOTA-PEG5-C6-DBCO

DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DOTA-PEG5-C6-DBCO Chemical Structure

DOTA-PEG5-C6-DBCO Chemical Structure

Size Price Stock Quantity
5 mg USD 430 In-stock
10 mg USD 680 In-stock
25 mg USD 1360 In-stock
50 mg USD 2170 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

DOTA-PEG5-C6-DBCO Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-PEG5-C6-DBCO Related Antibodies
Molecular Weight

982.13

Formula

C49H71N7O14
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCCCC(NCCOCCOCCOCCOCCOCCNC(CN4CCN(CCN(CCN(CC4)CC(O)=O)CC(O)=O)CC(O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (127.27 mM; ultrasonic and warming and heat to 60°C)

DMSO : 125 mg/mL (127.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0182 mL 5.0910 mL 10.1820 mL
5 mM 0.2036 mL 1.0182 mL 2.0364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 96.40%

SDS (251 KB)

COA (256 KB) HNMR (338 KB) RP-HPLC (205 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.0182 mL 5.0910 mL 10.1820 mL 25.4549 mL
5 mM 0.2036 mL 1.0182 mL 2.0364 mL 5.0910 mL
10 mM 0.1018 mL 0.5091 mL 1.0182 mL 2.5455 mL
15 mM 0.0679 mL 0.3394 mL 0.6788 mL 1.6970 mL
20 mM 0.0509 mL 0.2545 mL 0.5091 mL 1.2727 mL
25 mM 0.0407 mL 0.2036 mL 0.4073 mL 1.0182 mL
30 mM 0.0339 mL 0.1697 mL 0.3394 mL 0.8485 mL
40 mM 0.0255 mL 0.1273 mL 0.2545 mL 0.6364 mL
50 mM 0.0204 mL 0.1018 mL 0.2036 mL 0.5091 mL
60 mM 0.0170 mL 0.0848 mL 0.1697 mL 0.4242 mL
80 mM 0.0127 mL 0.0636 mL 0.1273 mL 0.3182 mL
100 mM 0.0102 mL 0.0509 mL 0.1018 mL 0.2545 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DOTA-PEG5-C6-DBCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-PEG5-C6-DBCOPROTAC LinkersInhibitorinhibitorinhibit

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