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  3. Biochemical Assay Reagents
  4. DOTA-Thiol

DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.

For research use only. We do not sell to patients.

DOTA-Thiol Chemical Structure

DOTA-Thiol Chemical Structure

CAS No. : 865470-67-3

Size Price Stock Quantity
5 mg USD 85 In-stock
10 mg USD 140 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

DOTA-Thiol Related Antibodies

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Description

DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.

Molecular Weight

463.55

Formula

C18H33N5O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(NCCS)=O)CC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (539.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 125 mg/mL (269.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1573 mL 10.7863 mL 21.5726 mL
5 mM 0.4315 mL 2.1573 mL 4.3145 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.1573 mL 10.7863 mL 21.5726 mL 53.9316 mL
5 mM 0.4315 mL 2.1573 mL 4.3145 mL 10.7863 mL
10 mM 0.2157 mL 1.0786 mL 2.1573 mL 5.3932 mL
15 mM 0.1438 mL 0.7191 mL 1.4382 mL 3.5954 mL
20 mM 0.1079 mL 0.5393 mL 1.0786 mL 2.6966 mL
25 mM 0.0863 mL 0.4315 mL 0.8629 mL 2.1573 mL
30 mM 0.0719 mL 0.3595 mL 0.7191 mL 1.7977 mL
40 mM 0.0539 mL 0.2697 mL 0.5393 mL 1.3483 mL
50 mM 0.0431 mL 0.2157 mL 0.4315 mL 1.0786 mL
60 mM 0.0360 mL 0.1798 mL 0.3595 mL 0.8989 mL
80 mM 0.0270 mL 0.1348 mL 0.2697 mL 0.6741 mL
100 mM 0.0216 mL 0.1079 mL 0.2157 mL 0.5393 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DOTA-Thiol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-Thiol865470-67-3Biochemical Assay ReagentsInhibitorinhibitorinhibit

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