2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Dovitinib dilactic acid

Dovitinib dilactic acid  (Synonyms: CHIR-258 dilactic acid; TKI258 dilactic acid)

Cat. No.: HY-13892
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Dovitinib (dilactic acid) is an orally active inhibitor of VEGF kinase. Dovitinib (dilactic acid) inhibits receptor tyrosine kinases (RTKs) involved in solid and hematologic cancers and tumor angiogenesis.

For research use only. We do not sell to patients.

Dovitinib dilactic acid Chemical Structure

Dovitinib dilactic acid Chemical Structure

CAS No. : 852433-84-2

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Dovitinib dilactic acid Related Antibodies

Top Publications Citing Use of Products

    Dovitinib dilactic acid purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2020 May 7;8:287.  [Abstract]

    Determination in L3.6 cells of FGF2-induced FGFR phosphorylation by Western blot in the presence of Dovitinib. FGFR1 and alpha-Tubulin are used as loading controls.

    Dovitinib dilactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.  [Abstract]

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

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    Description

    Dovitinib (dilactic acid) is an orally active inhibitor of VEGF kinase. Dovitinib (dilactic acid) inhibits receptor tyrosine kinases (RTKs) involved in solid and hematologic cancers and tumor angiogenesis[1].

    Molecular Weight

    572.59

    Formula

    C27H33FN6O7
    CAS No.
    SMILES

    CC(O)C(O)=O.CC(O)C(O)=O.O=C1NC2=C(C(F)=CC=C2)C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 30 mg/mL (52.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

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    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7465 mL 8.7323 mL 17.4645 mL
    5 mM 0.3493 mL 1.7465 mL 3.4929 mL
    View the Complete Stock Solution Preparation Table

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    Complete Stock Solution Preparation Table

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7465 mL 8.7323 mL 17.4645 mL 43.6613 mL
    5 mM 0.3493 mL 1.7465 mL 3.4929 mL 8.7323 mL
    10 mM 0.1746 mL 0.8732 mL 1.7465 mL 4.3661 mL
    15 mM 0.1164 mL 0.5822 mL 1.1643 mL 2.9108 mL
    20 mM 0.0873 mL 0.4366 mL 0.8732 mL 2.1831 mL
    25 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.7465 mL
    30 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4554 mL
    40 mM 0.0437 mL 0.2183 mL 0.4366 mL 1.0915 mL
    50 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.8732 mL
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    Dovitinib dilactic acid Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dovitinib852433-84-2CHIR-258TKI258CHIR258CHIR 258TKI 258TKI-258VEGFRVascular endothelial growth factor receptorVascular endothelial growth factorVEGFSolid cancerHmatologic cancerInhibitorinhibitorinhibit

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