Dovitinib dilactic acid (Synonyms: CHIR-258 dilactic acid; TKI258 dilactic acid)

Cat. No.: HY-13892: FAQs
Data Sheet Handling Instructions

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Dovitinib (dilactic acid) is an orally active inhibitor of VEGF kinase. Dovitinib (dilactic acid) inhibits receptor tyrosine kinases (RTKs) involved in solid and hematologic cancers and tumor angiogenesis.

For research use only. We do not sell to patients.

Dovitinib dilactic acid Chemical Structure

CAS No. : 852433-84-2

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Other In-stock Forms of Dovitinib dilactic acid:

Dovitinib lactate Dovitinib

Other Forms of Dovitinib dilactic acid:

8 Publications Citing Use of MCE Dovitinib dilactic acid

: Dovitinib dilactic acid purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2020 May 7;8:287. [Abstract]; Determination in L3.6 cells of FGF2-induced FGFR phosphorylation by Western blot in the presence of Dovitinib. FGFR1 and alpha-Tubulin are used as loading controls.

: Dovitinib dilactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]; BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

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•Related Small Molecules:

•Related Proteins:

View All VEGFR Isoform Specific Products:

View All Isoforms

VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

572.59

Formula

C₂₇H₃₃FN₆O₇

CAS No.

852433-84-2

SMILES

CC(O)C(O)=O.CC(O)C(O)=O.O=C1NC2=C(C(F)=CC=C2)C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL (52.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7465 mL	8.7323 mL	17.4645 mL
5 mM	0.3493 mL	1.7465 mL	3.4929 mL
10 mM	0.1746 mL	0.8732 mL	1.7465 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhu, S., et al. The Chemical Development of CHIR-258. CHIMIA International Journal for Chemistry, 60(9), 584–592.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7465 mL	8.7323 mL	17.4645 mL	43.6613 mL
	5 mM	0.3493 mL	1.7465 mL	3.4929 mL	8.7323 mL
	10 mM	0.1746 mL	0.8732 mL	1.7465 mL	4.3661 mL
	15 mM	0.1164 mL	0.5822 mL	1.1643 mL	2.9108 mL
	20 mM	0.0873 mL	0.4366 mL	0.8732 mL	2.1831 mL
	25 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.7465 mL
	30 mM	0.0582 mL	0.2911 mL	0.5822 mL	1.4554 mL
	40 mM	0.0437 mL	0.2183 mL	0.4366 mL	1.0915 mL
	50 mM	0.0349 mL	0.1746 mL	0.3493 mL	0.8732 mL

Dovitinib dilactic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dovitinib852433-84-2CHIR-258TKI258CHIR258CHIR 258TKI 258TKI-258VEGFRVascular endothelial growth factor receptorVascular endothelial growth factorVEGFSolid cancerHmatologic cancerInhibitorinhibitorinhibit

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