DPI-3290  (Synonyms: Org 41793)

DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with K_i values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively。DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity^[1].

DPI-3290 (Org 41793) (intravenous; 0.05 mg/kg) produces a 50% antinociceptive response in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

487.61

C₃₀H₃₄FN₃O₂

182417-73-8

O=C(N(C1=CC=CC(F)=C1)C)C2=CC=CC([C@@H](N3[C@@H](C)CN(CC=C)[C@H](C)C3)C4=CC=CC(O)=C4)=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gengo PJ, et al. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. J Pharmacol Exp Ther. 2003 Dec;307(3):1221-6.  [Content Brief]