2. GPCR/G Protein
  3. Adenosine Receptor
  4. DPTN dihydrochloride

DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively.

For research use only. We do not sell to patients.

DPTN dihydrochloride Chemical Structure

DPTN dihydrochloride Chemical Structure

CAS No. : 325767-87-1

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Based on 1 publication(s) in Google Scholar

DPTN dihydrochloride Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively[1].

IC50 & Target[1]

hA3

1.65 nM (Ki)

In Vitro

DPTN is indeed a potent antagonist for human, mouse, and rat A3ARs . DPTN is weaker at mouse and rat compared with human A3AR and has reduced selectivity (about 20-fold vs A2BAR).[1].
The Binding affinity of BNPT (10 μM) is tested in membranes of transfected HEK293 cells, the Ki values are 162 ± 49, 121 ± 42, 230 ± 40, and 1.65 ± 0.57 nM for hA1, hA2A, hA2B, and hA3, respectively[1].
DPTN’s Ki values at respective A1, A2A, A2B, and A3 receptors are 411, 830, 189, and 9.61 nM (mouse); and 333, 1147, 163, and 8.53 nM (rat) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DPTN dihydrochloride Related Antibodies
Molecular Weight

459.39

Formula

C22H20Cl2N4OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CN=C1)NC2=NC(C3=CC(C)=CC(C)=C3)=C(C4=CC=NC=C4)S2.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1768 mL 10.8840 mL 21.7680 mL
5 mM 0.4354 mL 2.1768 mL 4.3536 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1768 mL 10.8840 mL 21.7680 mL 54.4200 mL
5 mM 0.4354 mL 2.1768 mL 4.3536 mL 10.8840 mL
10 mM 0.2177 mL 1.0884 mL 2.1768 mL 5.4420 mL
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DPTN dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPTN325767-87-1Adenosine ReceptorP1 receptorA3ARInhibitorinhibitorinhibit

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