2. Cytoskeleton
  3. Dynamin
  4. DRP1i27 dihydrochloride

DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury.

For research use only. We do not sell to patients.

DRP1i27 dihydrochloride Chemical Structure

DRP1i27 dihydrochloride Chemical Structure

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1 mg USD 190 In-stock
5 mg USD 560 In-stock
10 mg USD 900 In-stock
25 mg USD 1900 In-stock
50 mg USD 3050 In-stock
100 mg USD 4800 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of DRP1i27 dihydrochloride:

DRP1i27 dihydrochloride Related Antibodies

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Description

DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].

In Vitro

DRP1i27 (0-50 μM) dihydrochloride directly binds to and inhibits GTPase activity of human Drp1[1].
DRP1i27 (0-50 μM) dihydrochloride is able to increase cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner[1].
DRP1i27 dihydrochloride has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DRP1i27 dihydrochloride Related Antibodies
Molecular Weight

439.38

Formula

C20H28Cl2N6O
Appearance

Solid

Color

Light yellow to brown

SMILES

[H]Cl.CC1=C(NC=N1)CN2C[C@@H]3CC[C@@H](N(C3)CC4=CC=C(O4)C5=NNC=C5)C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2759 mL 11.3797 mL 22.7593 mL
5 mM 0.4552 mL 2.2759 mL 4.5519 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2759 mL 11.3797 mL 22.7593 mL 56.8984 mL
5 mM 0.4552 mL 2.2759 mL 4.5519 mL 11.3797 mL
10 mM 0.2276 mL 1.1380 mL 2.2759 mL 5.6898 mL
15 mM 0.1517 mL 0.7586 mL 1.5173 mL 3.7932 mL
20 mM 0.1138 mL 0.5690 mL 1.1380 mL 2.8449 mL
25 mM 0.0910 mL 0.4552 mL 0.9104 mL 2.2759 mL
30 mM 0.0759 mL 0.3793 mL 0.7586 mL 1.8966 mL
40 mM 0.0569 mL 0.2845 mL 0.5690 mL 1.4225 mL
50 mM 0.0455 mL 0.2276 mL 0.4552 mL 1.1380 mL
60 mM 0.0379 mL 0.1897 mL 0.3793 mL 0.9483 mL
80 mM 0.0284 mL 0.1422 mL 0.2845 mL 0.7112 mL
100 mM 0.0228 mL 0.1138 mL 0.2276 mL 0.5690 mL
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DRP1i27 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DRP1i27DynaminIschaemiareperfusionHL-1 cellsHuman foreskin fibroblastsInhibitorinhibitorinhibit

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