2. GPCR/G Protein
  3. PTHR
  4. DS08210767

DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.

For research use only. We do not sell to patients.

DS08210767 Chemical Structure

DS08210767 Chemical Structure

CAS No. : 2376334-75-5

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1 mg USD 212 In-stock
5 mg USD 530 In-stock
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25 mg USD 1270 In-stock
50 mg USD 1778 In-stock
100 mg USD 2311 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM[1].

IC50 & Target

IC50: 90 nM (PTHR1)[1]
Cellular Effect
Cell Line Type Value Description References
CHO-K1 IC50
0.09 μM
Compound: 5
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
[PMID: 32345459]
Molecular Weight

513.67

Formula

C31H39N5O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1(N=C(C2=CC=C(C=C2N(C1=O)C3=CC=C(C=C3)NCCNC4CCOCC4)C#N)C5CCCCC5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.73 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9468 mL 9.7339 mL 19.4678 mL
5 mM 0.3894 mL 1.9468 mL 3.8936 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9468 mL 9.7339 mL 19.4678 mL 48.6694 mL
5 mM 0.3894 mL 1.9468 mL 3.8936 mL 9.7339 mL
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DS08210767 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS082107672376334-75-5DS 08210767DS-08210767PTHRParathyroid hormone receptorInhibitorinhibitorinhibit

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