2. PROTAC
  3. PROTACs
  4. dTAG-47-NEG

dTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN). dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47.

For research use only. We do not sell to patients.

dTAG-47-NEG Chemical Structure

dTAG-47-NEG Chemical Structure

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1 mg USD 400 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

dTAG-47-NEG Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

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Description

dTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN). dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47[1].

In Vitro

dTAG-47-NEG Related Antibodies

Cell Viability Assay[1]

Cell Line: FKBP12[WT], FKBP12[F36V]
Concentration: 100 nM
Incubation Time: 24 hours
Result: Negative control for dTAG-47.
Molecular Weight

1062.25

Formula

C59H75N5O13
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2C(NCCC2)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 106.22 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9414 mL 4.7070 mL 9.4140 mL
5 mM 0.1883 mL 0.9414 mL 1.8828 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9414 mL 4.7070 mL 9.4140 mL 23.5349 mL
5 mM 0.1883 mL 0.9414 mL 1.8828 mL 4.7070 mL
10 mM 0.0941 mL 0.4707 mL 0.9414 mL 2.3535 mL
15 mM 0.0628 mL 0.3138 mL 0.6276 mL 1.5690 mL
20 mM 0.0471 mL 0.2353 mL 0.4707 mL 1.1767 mL
25 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9414 mL
30 mM 0.0314 mL 0.1569 mL 0.3138 mL 0.7845 mL
40 mM 0.0235 mL 0.1177 mL 0.2353 mL 0.5884 mL
50 mM 0.0188 mL 0.0941 mL 0.1883 mL 0.4707 mL
60 mM 0.0157 mL 0.0784 mL 0.1569 mL 0.3922 mL
80 mM 0.0118 mL 0.0588 mL 0.1177 mL 0.2942 mL
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dTAG-47-NEG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dTAG-47-NEGPROTACsdTAG-47 analogCRBNheterobifunctionalnegative controlcereblonInhibitorinhibitorinhibit

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