2. PROTAC Apoptosis Immunology/Inflammation Cell Cycle/DNA Damage Autophagy
  3. PROTACs FKBP
  4. dTAGV-1-NEG

dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12F36V-selective degrader.

For research use only. We do not sell to patients.

dTAGV-1-NEG Chemical Structure

dTAGV-1-NEG Chemical Structure

CAS No. : 2451573-87-6

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Based on 1 publication(s) in Google Scholar

Other Forms of dTAGV-1-NEG:

dTAGV-1-NEG Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12F36V-selective degrader[1].

In Vitro

dTAGV-1-NEG (1-10 μM; 24 h) not induces the degradation of FKBP12F36V-Nluc on 293FT FKBP12F36V-Nluc or FKBP12WT-Nluc cells[1].
dTAGV-1-NEG (500 nM; 24 h) dose not induce the degradation of KRASG12V protein in PATU-8902 FKBP12F36V-KRASG12V and KRAS?/? cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

dTAGV-1-NEG Related Antibodies

Western Blot Analysis[1]

Cell Line: PATU-8902 FKBP12F36V-KRASG12V, KRAS−/− cells
Concentration: 500 nM
Incubation Time: 1-24 h
Result: Not induced the degradation of KRASG12V protein.
Molecular Weight

1247.54

Formula

C68H90N6O14S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@H](O)C4)=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (80.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8016 mL 4.0079 mL 8.0158 mL
5 mM 0.1603 mL 0.8016 mL 1.6032 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8016 mL 4.0079 mL 8.0158 mL 20.0394 mL
5 mM 0.1603 mL 0.8016 mL 1.6032 mL 4.0079 mL
10 mM 0.0802 mL 0.4008 mL 0.8016 mL 2.0039 mL
15 mM 0.0534 mL 0.2672 mL 0.5344 mL 1.3360 mL
20 mM 0.0401 mL 0.2004 mL 0.4008 mL 1.0020 mL
25 mM 0.0321 mL 0.1603 mL 0.3206 mL 0.8016 mL
30 mM 0.0267 mL 0.1336 mL 0.2672 mL 0.6680 mL
40 mM 0.0200 mL 0.1002 mL 0.2004 mL 0.5010 mL
50 mM 0.0160 mL 0.0802 mL 0.1603 mL 0.4008 mL
60 mM 0.0134 mL 0.0668 mL 0.1336 mL 0.3340 mL
80 mM 0.0100 mL 0.0501 mL 0.1002 mL 0.2505 mL
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dTAGV-1-NEG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dTAGV-1-NEG2451573-87-6PROTACsFKBPFK506-binding proteinvon Hippel-Lindau (VHL) E3 ligaseheterobifunctional negative controldTAGV-1KRASG12VInhibitorinhibitorinhibit

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