dTAGV-1-NEG TFA

Cat. No.: HY-145514B: FAQs
Data Sheet Handling Instructions

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dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12^F36V-selective degrader.

For research use only. We do not sell to patients.

dTAGV-1-NEG TFA Chemical Structure

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Other Forms of dTAGV-1-NEG TFA:

dTAGV-1 TFA Get quote
dTAGV-1 hydrochloride Get quote
dTAGV-1-NEG Get quote

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•Related Small Molecules:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12^F36V-selective degrader^[1].

In Vitro

dTAGV-1-NEG TFA (1-10 μM; 24 h) not induces the degradation of FKBP12^F36V-Nluc on 293FT FKBP12^F36V-Nluc or FKBP12^WT-Nluc cells^[1].
dTAGV-1-NEG TFA (500 nM; 24 h) dose not induce the degradation of KRAS^G12V protein in PATU-8902 FKBP12^F36V-KRASG12V and KRAS^?/? cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	PATU-8902 FKBP12^F36V-KRASG12V, KRAS^−/− cells
Concentration:	50, 500 nM
Incubation Time:	24 hours
Result:	Not induced the degradation of KRAS^G12V protein.

Cell Viability Assay^[1]

Cell Line:	EWS502 FKBP12F36V-GFP cells
Concentration:	1 μM
Incubation Time:	0, 2, 4, 6, 8 days
Result:	Showed relative growth of cells same as the control group, higher than dTAGV-1 treated group.

Molecular Weight

1361.56

Formula

C₇₀H₉₁F₃N₆O₁₆S

SMILES

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@H](O)C4)=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nabet B, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11(1):4687. [Content Brief]

dTAGV-1-NEG TFA Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dTAGV-1-NEGPROTACsFKBPFK506-binding proteinvon Hippel-LindauVHLE3 ligaseheterobifunctional negative controldTAGV-1KRASG12VInhibitorinhibitorinhibit

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