DTSSP Crosslinker

Name: DTSSP Crosslinker
Brand: MedChemExpress
SKU: HY-126349
Rating: 4.5 (1 reviews)

Cat. No.: HY-126349 Purity: 98.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DTSSP Crosslinker Chemical Structure

CAS No. : 81069-02-5

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DTSSP Crosslinker:

DTSSP Crosslinker disodium Get quote

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

564.54

Formula

C₁₄H₁₆N₂O₁₄S₄

CAS No.

81069-02-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(C(S(=O)(O)=O)CC1=O)=O)CCSSCCC(ON2C(C(S(=O)(O)=O)CC2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (221.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7714 mL	8.8568 mL	17.7135 mL
5 mM	0.3543 mL	1.7714 mL	3.5427 mL
10 mM	0.1771 mL	0.8857 mL	1.7714 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.87%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (246 KB) HNMR (426 KB) LCMS (311 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7714 mL	8.8568 mL	17.7135 mL	44.2838 mL
	5 mM	0.3543 mL	1.7714 mL	3.5427 mL	8.8568 mL
	10 mM	0.1771 mL	0.8857 mL	1.7714 mL	4.4284 mL
	15 mM	0.1181 mL	0.5905 mL	1.1809 mL	2.9523 mL
	20 mM	0.0886 mL	0.4428 mL	0.8857 mL	2.2142 mL
	25 mM	0.0709 mL	0.3543 mL	0.7085 mL	1.7714 mL
	30 mM	0.0590 mL	0.2952 mL	0.5905 mL	1.4761 mL
	40 mM	0.0443 mL	0.2214 mL	0.4428 mL	1.1071 mL
	50 mM	0.0354 mL	0.1771 mL	0.3543 mL	0.8857 mL
	60 mM	0.0295 mL	0.1476 mL	0.2952 mL	0.7381 mL
	80 mM	0.0221 mL	0.1107 mL	0.2214 mL	0.5535 mL
	100 mM	0.0177 mL	0.0886 mL	0.1771 mL	0.4428 mL