2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DTSSP Crosslinker

DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DTSSP Crosslinker Chemical Structure

DTSSP Crosslinker Chemical Structure

CAS No. : 81069-02-5

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5 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of DTSSP Crosslinker:

DTSSP Crosslinker Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Disulfide Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DTSSP Crosslinker Related Antibodies
Molecular Weight

564.54

Formula

C14H16N2O14S4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(C(S(=O)(O)=O)CC1=O)=O)CCSSCCC(ON2C(C(S(=O)(O)=O)CC2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (221.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7714 mL 8.8568 mL 17.7135 mL
5 mM 0.3543 mL 1.7714 mL 3.5427 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.87%

COA (246 KB) HNMR (470 KB) LCMS (311 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7714 mL 8.8568 mL 17.7135 mL 44.2838 mL
5 mM 0.3543 mL 1.7714 mL 3.5427 mL 8.8568 mL
10 mM 0.1771 mL 0.8857 mL 1.7714 mL 4.4284 mL
15 mM 0.1181 mL 0.5905 mL 1.1809 mL 2.9523 mL
20 mM 0.0886 mL 0.4428 mL 0.8857 mL 2.2142 mL
25 mM 0.0709 mL 0.3543 mL 0.7085 mL 1.7714 mL
30 mM 0.0590 mL 0.2952 mL 0.5905 mL 1.4761 mL
40 mM 0.0443 mL 0.2214 mL 0.4428 mL 1.1071 mL
50 mM 0.0354 mL 0.1771 mL 0.3543 mL 0.8857 mL
60 mM 0.0295 mL 0.1476 mL 0.2952 mL 0.7381 mL
80 mM 0.0221 mL 0.1107 mL 0.2214 mL 0.5535 mL
100 mM 0.0177 mL 0.0886 mL 0.1771 mL 0.4428 mL
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DTSSP Crosslinker Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DTSSP Crosslinker81069-02-5ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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