Dual AChE-MAO B-IN-1 

Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC₅₀=550 nM) and MAO B (IC₅₀=8.2 nM). Dual AChE-MAO B-IN-1 behaves as a safe and metabolically stable neuroprotective agent, devoid of cytochrome liability^[1].

Dual AChE-MAO B-IN-1 (compound 15) (1-100 μM) has no significant effect on the viability of human neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells even at concentration up to 100 μM^[1].
Dual AChE-MAO B-IN-1 (compound 15) (0.1-5 μM, 24 h) can reduce neuronal damage produced by Aβ1-42 and H₂O₂ and completely shut down N-methyl-d-aspartate (NMDA) toxicity in neuroblastoma cultures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

417.45

C₂₃H₂₅F₂NO₄

OCC(C(C=C1)=C(O2)C=C1OCC3=CC=C(CN(C)CCCC(F)F)C=C3)=CC2=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rullo M, et al. Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies. J Med Chem. 2022;65(5):3962-3977.  [Content Brief]