Dynole 2−24

Cat. No.: HY-145080 Purity: 98.13%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC₅₀=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC_₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis

For research use only. We do not sell to patients.

Dynole 2−24 Chemical Structure

CAS No. : 1416313-72-8

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	1.9 μM Compound: 24	Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins	[PMID: 23167654]

Molecular Weight

371.60

Formula

C₂₄H₄₁N₃

CAS No.

1416313-72-8

Appearance

Oil

Color

Colorless to light yellow

SMILES

CN(C)CCCN1C=C(CNCCCCCCCCCC)C2=C1C=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (269.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6911 mL	13.4553 mL	26.9107 mL
5 mM	0.5382 mL	2.6911 mL	5.3821 mL
10 mM	0.2691 mL	1.3455 mL	2.6911 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.13%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (242 KB) HNMR (149 KB) RP-HPLC (160 KB) LCMS (226 KB)

Handling Instructions (2659 KB)

References

[1]. Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56(1):46-59. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6911 mL	13.4553 mL	26.9107 mL	67.2766 mL
	5 mM	0.5382 mL	2.6911 mL	5.3821 mL	13.4553 mL
	10 mM	0.2691 mL	1.3455 mL	2.6911 mL	6.7277 mL
	15 mM	0.1794 mL	0.8970 mL	1.7940 mL	4.4851 mL
	20 mM	0.1346 mL	0.6728 mL	1.3455 mL	3.3638 mL
	25 mM	0.1076 mL	0.5382 mL	1.0764 mL	2.6911 mL
	30 mM	0.0897 mL	0.4485 mL	0.8970 mL	2.2426 mL
	40 mM	0.0673 mL	0.3364 mL	0.6728 mL	1.6819 mL
	50 mM	0.0538 mL	0.2691 mL	0.5382 mL	1.3455 mL
	60 mM	0.0449 mL	0.2243 mL	0.4485 mL	1.1213 mL
	80 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.8410 mL
	100 mM	0.0269 mL	0.1346 mL	0.2691 mL	0.6728 mL

Dynole 2−24 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dynole 2−241416313-72-8Dynaminclathrin mediated endocytosisdynamin GTPasenontoxicselectivityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Dynole 2−24

Customer Review

Dynole 2−24 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Dynole 2−24 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report